RELAXATION OF ISOLATED BOVINE CORONARY-ARTERIES BY VASOACTIVE-INTESTINAL-PEPTIDE

被引：19
作者：
ITOH, H [1 ]
LEDERIS, KP [1 ]
RORSTAD, OP [1 ]
机构：
[1] UNIV CALGARY,DEPT MED,DEPT PHARMACOL & THERAPEUT,ENDOCRINE RES GRP,3330 HOSP DR NW,CALGARY T2N 4NI,ALBERTA,CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 03期
基金：
英国医学研究理事会;
关键词：
Coronary artery; PHI (peptide histidine isoleucine); Vasorelaxation; VIP (vasoactive intestinal peptide);
D O I：
10.1016/0014-2999(90)90079-L
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The relaxant action of vasoactive intestinal peptide (VIP) was investigated using helical strips of four major branches of bovine coronary arteries. The concentration of VIP causing 50 percent of maximal relaxation ranged from 23 to 90 nM. Preincubation of arterial strips with VIP shifted the concentration-response curves for contractions elicited by potassium chloride or prostaglandin F2α to the right. The relaxant effect of VIP was retained following removal of the vascular endothelium or in the absence of extracellular calcium. The structurally homologous peptides porcine and human peptide histidine isoleucine (PHI) were less potent than was VIP. It is concluded that there are functional receptors for VIP in bovine coronary arteries. © 1990.
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页码：199 / 205
页数：7
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