GENETIC-POLYMORPHISM OF HUMAN-SERUM TRANSFERRIN IN THE SWISS POPULATION - EVIDENCE FOR 3 NEW TRANSFERRIN-VARIANTS

被引：6
作者：
SCHERZ, R
REBER, B
PFLUGSHAUPT, R
BUTLER, R
机构：
[1] Blood Transfusion Service, Src, Central Laboratory, Bern
来源：
ELECTROPHORESIS | 1985年 / 6卷 / 11期
关键词：
D O I：
10.1002/elps.1150061112
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic polymorphism of transferrin (Tf) was studied in 473 healthy Swiss blood donors and 236 nonrelated individuals engaged in cases of disputed paternity. Gene frequencies were: TfC1 = 0.7727, TfC2 = 0.1634, TfC3 = 0.0573. Several rare alleles were observed, the frequency of the total of which was 0.0066. Three obviously new Tf alleles were detected. The phenotype distribution was in agreement with the Hardy Weinberg equilibrium. Among 113 mother/child pairs no phenotypes contradictory to the mendelian law were observed. The transferrin system represents a useful parameter in routine paternity testing. Its average chance of exclusion (without rare alleles) is 18.19%. Copyright © 1985 VCH Verlagsgesellschaft mbH
引用
收藏
页码：569 / 571
页数：3
相关论文
共 16 条
[1]  
ABBOZZO G, 1975, 6 INT TAG GES FOR BL, P541
[2]   TRANSFERRIN (TF) SUBTYPES IN UNITED-STATES AMERINDIANS, WHITES AND BLACKS USING THIN-LAYER AGAROSE GELS - REPORT ON A NEW VARIANT TFC8 [J].
DYKES, DD ;
DEFURIO, CM ;
POLESKY, HF .
ELECTROPHORESIS, 1982, 3 (03) :162-164
[3]   TRANSFERRIN VARIANTS IN TUSCANY (ITALY) - EVIDENCE FOR 2 NEW TF ALLELES [J].
GIARI, A ;
WEIDINGER, S ;
DOMENICI, R ;
BARGAGNA, M .
HUMAN GENETICS, 1985, 69 (03) :284-286
[4]   ISOELECTRIC-FOCUSING WITH IMMOBILIZED PH GRADIENTS FOR THE ANALYSIS OF TRANSFERRIN (TF) SUBTYPES AND VARIANTS [J].
GORG, A ;
WESER, J ;
WESTERMEIER, R ;
POSTEL, W ;
WEIDINGER, S ;
PATUTSCHNICK, W ;
CLEVE, H .
HUMAN GENETICS, 1983, 64 (03) :222-226
[5]  
KRUGER HJ, 1984, 18TH C INT SOC BLOOD, P188
[6]   TRANSFERRIN - EVIDENCE FOR 2 COMMON SUBTYPES OF TFC ALLELE [J].
KUHNL, P ;
SPIELMANN, W .
HUMAN GENETICS, 1978, 43 (01) :91-95
[7]  
KUHNL P, 1984, 18TH P C INT SOC BLO, P187
[8]  
KUHNL P, 1984, 18TH C INT SOC BLOOD, P59
[9]   A SILENT TRANSFERRIN ALLELE IN A FINNISH FAMILY [J].
LUKKA, M ;
EHNHOLM, C .
HUMAN HEREDITY, 1985, 35 (03) :157-160
[10]  
RAO PR, 1984, 18TH C INT SOC BLOOD, P60
12