Colonic necrosis and perforation due to calcium polystyrene sulfonate in a uraemic patient: a case report

被引：10

作者：

Akagun, Tulin ^{[1
]}

Yazici, Halil ^{[1
]}

Gulluoglu, Mine G. ^{[2
]}

Yegen, Gulcin ^{[2
]}

Turkmen, Aydin ^{[1
]}

机构：

[1] Istanbul Univ, Div Nephrol, Dept Internal Med, Istanbul Fac Med, Istanbul, Turkey

[2] Istanbul Univ, Dept Pathol, Istanbul Fac Med, Istanbul, Turkey

来源：

CLINICAL KIDNEY JOURNAL | 2011年 / 4卷 / 06期

关键词：

calcium polystyrene sulfonate; chronic kidney disease; colon perforation; hyperkalaemia;

D O I：

10.1093/ndtplus/sfr113

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sodium or calcium polystyrene sulfonate (Kayexalate or analog) is an ion-exchange resin commonly used to treat hyperkalaemia in patients with chronic kidney disease. It is known to cause digestive complications, such as nausea, vomiting and constipation. Although rare, colonic necrosis and perforation are very severe complications associated with the medication. In this case report, we present a case of calcium polystyrene sulfonate-induced colonic necrosis and perforation to remind clinicians of this rare, but dangerous, toxicity associated with this commonly used medication.

引用

页码：402 / 403

页数：2

共 7 条

[1]

Dardik A, 2000, SOUTH MED J, V93, P511

[2] EFFECT OF 3 LAXATIVES AND A CATION-EXCHANGE RESIN ON FECAL SODIUM AND POTASSIUM EXCRETION [J].

EMMETT, M ;

HOOTKINS, RE ;

FINE, KD ;

ANA, CAS ;

PORTER, JL ;

FORDTRAN, JS .

GASTROENTEROLOGY, 1995, 108 (03) :752-760

[3] INTESTINAL NECROSIS ASSOCIATED WITH POSTOPERATIVE ORALLY-ADMINISTERED SODIUM POLYSTYRENE SULFONATE IN SORBITOL [J].

GERSTMAN, BB ;

KIRKMAN, R ;

PLATT, R .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1992, 20 (02) :159-161

[4]

LILLEMOE KD, 1987, SURGERY, V101, P267

[5] Intestinal Necrosis due to Sodium Polystyrene Sulfonate (Kayexalate) in Sorbitol [J].

McGowan, C. E. ;

Saha, S. ;

Chu, G. ;

Resnick, M. B. ;

Moss, S. F. .

SOUTHERN MEDICAL JOURNAL, 2009, 102 (05) :493-497

[6] Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (Kayexalate) in sorbitol - An underrecognized condition [J].

Rashid, A ;

Hamilton, SR .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (01) :60-69

[7] Acute colonic necrosis associated with sodium polystyrene sulfonate (Kayexalate) enemas in a critically ill patient: Case report and review of the literature [J].

Rogers, FB ;

Li, SC .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2001, 51 (02) :395-397

← 1 →