PNEUMOLYSIN STIMULATES PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA BY HUMAN MONONUCLEAR PHAGOCYTES

被引：149
|
作者：
HOULDSWORTH, S [1 ]
ANDREW, PW [1 ]
MITCHELL, TJ [1 ]
机构：
[1] UNIV LEICESTER,DEPT MICROBIOL & IMMUNOL,LEICESTER LE1 9HN,ENGLAND
来源：
INFECTION AND IMMUNITY | 1994年 / 62卷 / 04期
关键词：
D O I：
10.1128/IAI.62.4.1501-1503.1994
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.
引用
收藏
页码：1501 / 1503
页数：3
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