HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PEPTIDES AT REDUCED TEMPERATURES - SEPARATION OF ISOMERS

被引：12

作者：

LEBL, M ^{[1
]}

FANG, S ^{[1
]}

HRUBY, VJ ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 586卷 / 01期

关键词：

D O I：

10.1016/0021-9673(91)80032-C

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cholecystokinin analogues containing N-methyl amino acids were studied by reversed-phase high-performance liquid chromatography at reduced temperatures. A reduction in temperature to -17-degrees-C led to lower efficiency, but at the same time separations of cis and trans isomers (and some impurities) were achieved. The velocity constants for cis-trans equilibria were calculated.

引用

页码：145 / 148

页数：4

共 14 条

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