PROLACTIN RESPONSES TO PHENYLALANINE AND TYROSINE IN PHENYLKETONURIA

被引：7

作者：

CARLSON, HE

HYMAN, DB

BAUMAN, C

KOCH, R

机构：

[1] CHILDRENS HOSP LOS ANGELES,DIV MED GENET,LOS ANGELES,CA

[2] VET ADM MED CTR,RES SERV,NORTHPORT,NY 11768

[3] SUNY STONY BROOK,DEPT MED,STONY BROOK,NY 11794

[4] SUNY STONY BROOK,DEPT PEDIAT,STONY BROOK,NY 11794

[5] UNIV SO CALIF,DEPT PEDIAT,LOS ANGELES,CA 90089

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1992年 / 41卷 / 05期

关键词：

D O I：

10.1016/0026-0495(92)90211-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In normal subjects, ingestion of tyrosine or phenylalanine stimulates prolactin (PRL) secretion. In patients with phenylketonuria (PKU), we found normal PRL responses to phenylalanine, demonstrating that conversion of phenylalanine to tyrosine is not necessary for PRL stimulation. PKU patients also showed greater PRL responses to tyrosine during dietary phenylalanine restriction than when consuming an unrestricted diet; this finding is consistent with inhibition by phenylalanine of tyrosine transport across the blood-brain barrier. Such competitive inhibition of a normal brain function may serve as a model for some of the neurotoxic effects of phenylalanine in PKU. © 1992.

引用

页码：518 / 521

页数：4

共 20 条

[1] MODULATION OF THE ACTIONS OF TYROSINE BY ALPHA-2-ADRENOCEPTOR BLOCKADE [J].