DIPYRIDAMOLE POTENTIATES THE ANTI-AGGREGATING AND VASODILATOR ACTIVITY OF NITRIC-OXIDE

被引：45
作者：
BULT, H
FRET, HRL
JORDAENS, FH
HERMAN, AG
机构：
[1] University of Antwerp (UIA), Division of Pharmacology
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 01期
关键词：
AORTA(RABBIT); PLATELET AGGREGATION; DIPYRIDAMOLE; NITRIC OXIDE (NO); ENDOTHELIUM; ORGANIC NITRATES;
D O I：
10.1016/0014-2999(91)90629-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The interaction between dipyridamole and nitric oxide (NO) was studied using isolated rabbit platelets and segments of the rabbit aorta. Dipyridamole potentiated the anti-aggregating activity of authentic NO when platelet aggregation was induced by the thromboxane A2 mimetic U-46619 or adenosine diphosphate (ADP). This potentiation was also seen when washed rabbit platelets were exposed to aortic effluent containing endothelium-derived NO. In the thoracic aorta dipyridamole hardly influenced the endothelium-dependent relaxations induced by acetylcholine. However, dipyridamole clearly enhanced the dilatation caused by exogenous NO from four different sources, including endothelial cells.
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页码：1 / 8
页数：8
相关论文
共 39 条
[1]  
AHLNER J, 1986, ACTA PHARM TOXICOL C, V57, P88
[2]   PRIMARY SEQUENCE OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES AND THE DESIGN OF SELECTIVE INHIBITORS [J].
BEAVO, JA ;
REIFSNYDER, DH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (04) :150-155
[3]   PLATELET INHIBITION BY ENDOTHELIUM-DERIVED RELAXING FACTOR FROM THE RABBIT PERFUSED AORTA [J].
BULT, H ;
FRET, HRL ;
VANDENBOSSCHE, RM ;
HERMAN, AG .
BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (04) :1308-1314
[4]  
BULT H, IN PRESS THROMB HAEM
[5]  
BULT H, 1988, EUROPEAN J PHYSL, V412, pS44
[6]  
BULT H, 1989, J VASC MED BIOL, V1, P79
[7]  
BUSSE R, 1987, N-S ARCH PHARMACOL, V336, P566
[8]   ACETYLCHOLINE RELEASES ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR AND EDRF FROM RAT-BLOOD VESSELS [J].
CHEN, G ;
SUZUKI, H ;
WESTON, AH .
BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (04) :1165-1174
[9]   A PLATELET-INHIBITOR-DRUG TRIAL IN CORONARY-ARTERY BYPASS OPERATIONS - BENEFIT OF PERIOPERATIVE DIPYRIDAMOLE AND ASPIRIN THERAPY ON EARLY POSTOPERATIVE VEIN-GRAFT PATENCY [J].
CHESEBRO, JH ;
CLEMENTS, IP ;
FUSTER, V ;
ELVEBACK, LR ;
SMITH, HC ;
BARDSLEY, WT ;
FRYE, RL ;
HOLMES, DR ;
VLIETSTRA, RE ;
PLUTH, JR ;
WALLACE, RB ;
PUGA, FJ ;
ORSZULAK, TA ;
PIEHLER, JM ;
SCHAFF, HV ;
DANIELSON, GK .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (02) :73-78
[10]   EFFECT OF DIPYRIDAMOLE AND ASPIRIN ON LATE VEIN-GRAFT PATENCY AFTER CORONARY-BYPASS OPERATIONS [J].
CHESEBRO, JH ;
FUSTER, V ;
ELVEBACK, LR ;
CLEMENTS, IP ;
SMITH, HC ;
HOLMES, DR ;
BARDSLEY, WT ;
PLUTH, JR ;
WALLACE, RB ;
PUGA, FJ ;
ORSZULAK, TA ;
PIEHLER, JM ;
DANIELSON, GK ;
SCHAFF, HV ;
FRYE, RL .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (04) :209-214
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