DIPYRIDAMOLE POTENTIATES THE ANTI-AGGREGATING AND VASODILATOR ACTIVITY OF NITRIC-OXIDE

被引：45
作者：
BULT, H
FRET, HRL
JORDAENS, FH
HERMAN, AG
机构：
[1] University of Antwerp (UIA), Division of Pharmacology
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 01期
关键词：
AORTA(RABBIT); PLATELET AGGREGATION; DIPYRIDAMOLE; NITRIC OXIDE (NO); ENDOTHELIUM; ORGANIC NITRATES;
D O I：
10.1016/0014-2999(91)90629-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The interaction between dipyridamole and nitric oxide (NO) was studied using isolated rabbit platelets and segments of the rabbit aorta. Dipyridamole potentiated the anti-aggregating activity of authentic NO when platelet aggregation was induced by the thromboxane A2 mimetic U-46619 or adenosine diphosphate (ADP). This potentiation was also seen when washed rabbit platelets were exposed to aortic effluent containing endothelium-derived NO. In the thoracic aorta dipyridamole hardly influenced the endothelium-dependent relaxations induced by acetylcholine. However, dipyridamole clearly enhanced the dilatation caused by exogenous NO from four different sources, including endothelial cells.
引用
收藏
页码：1 / 8
页数：8
相关论文
共 39 条
1234