EVALUATION OF ANTIPEROXIDATIVE POTENTIAL OF ASCORBIC ACID ON BUSULFAN-INDUCED LIPID PEROXIDATION USING 4-HYDROXY-2-NONENAL AND NITRIC OXIDE AS MODEL MARKERS

被引：2

作者：

Ray, Supratim ^{[1
]}

机构：

[1] Dr BC Roy Coll Pharm & Allied Hlth Sci, Div Pharmaceut Chem, Durgapur 713206, W Bengal, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 03期

关键词：

Busulfan; Lipid peroxidation; Ascorbic acid; 4-hydroxy-2-nonenal; Nitric oxide;

D O I：

10.13040/IJPSR.0975-8232.3(3).896-00

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid peroxidation induction capacity of busulfan and the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation.

引用

页码：896 / 900

页数：5

共 3 条

[1] EVALUATION OF ANTIPEROXIDATIVE POTENTIAL OF WATER EXTRACT OF SPIRULINA PLATENSIS ON BUSULFAN-INDUCED LIPID PEROXIDATION USING 4-HYDROXY NONENAL AND NITRIC OXIDE AS MODEL MARKERS
Ray, Supratim
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2011, 1 (01): : L21 - L27
[2] Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker
Roy, Partha Pratim
Ray, Sarbani Dey
Ray, Supratim
BIOORGANIC CHEMISTRY, 2014, 56 : 1 - 7
[3] Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil
Eder, Erwin
Wacker, Matthias
Wanek, Paul
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2008, 654 (02) : 101 - 107

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