INCREASED AND ALTERED DNA-BINDING OF HUMAN P53 BY S AND G2/M BUT NOT G1 CYCLIN-DEPENDENT KINASES

被引：330
作者：
WANG, Y
PRIVES, C
机构：
来源：
NATURE | 1995年 / 376卷 / 6535期
关键词：
D O I：
10.1038/376088a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
CENTRAL to the role of p53 in cell regulation are its sequence-specific interactions with genes that control the cell cycle and apoptosis(1,2). p53 response elements contain two or more copies of a somewhat promiscuous consensus sequence: 5'-XXXC(A,T)(T, A)GYYY-3' (where X is a purine and Y is a pyrimidine) (ref, 3), The sequence-specific DNA-binding region of p53 resides in its central conserved region(4). Although this region itself is not known to he phosphorylated, the amino and carboxy termini of human p53 contain sites for phosphorylation by several protein kinases.
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页码：88 / 91
页数：4
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