CYCLIN-DEPENDENT KINASES AND PRB - REGULATORS OF THE PROLIFERATION DIFFERENTIATION SWITCH

被引：32

作者：

KRANENBURG, O

VANDEREB, AJ

ZANTEMA, A

机构：

[1] Department of Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, 2300 RA Leiden

来源：

FEBS LETTERS | 1995年 / 367卷 / 02期

关键词：

RETINOBLASTOMA GENE PRODUCT; DIFFERENTIATION; TUMORIGENESIS; CYCLIN-DEPENDENT KINASE;

D O I：

10.1016/0014-5793(95)00587-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retinoblastoma susceptibility gene (RBI) is essential for normal embryonic development. Loss of RBI leads to uncontrolled proliferation of a number of cell types but may also prevent proper terminal differentiation. The growth-suppressive and differentiation-inducing properties of pRb are impaired by cyclin-dependent kinase (cdk)-mediated phosphorylation. Hence, inhibition of cdk activity is probably a prerequisite for terminal differentiation. Indeed, forced cyclin or cdk expression tan prevent terminal differentiation in various cell types, probably through inhibition of pRb and, possibly, differentiation-specific transcription factors.

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页码：103 / 106

页数：4

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