NATURAL-KILLER-CELL STIMULATORY FACTOR (INTERLEUKIN-12 [IL-12]) INDUCES T-HELPER TYPE-1 (TH1)-SPECIFIC IMMUNE-RESPONSES AND INHIBITS THE DEVELOPMENT OF IL-4-PRODUCING TH CELLS

被引:1655
作者
MANETTI, R
PARRONCHI, P
GIUDIZI, MG
PICCINNI, MP
MAGGI, E
TRINCHIERI, G
ROMAGNANI, S
机构
[1] UNIV FLORENCE, IST CLIN MED 3, DIV CLIN IMMUNOL & ALLERGY, VIALE MORGAGNI 85, I-50134 FLORENCE, ITALY
[2] WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA
关键词
D O I
10.1084/jem.177.4.1199
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effects exerted on the in vitro development of antigen-specific T cell lines and T cell clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were examined. T cell lines specific for Dermatophagoides pteronyssinus group I (Der p I) derived in the presence of IL-12 exhibited reduced ability to produce IL-4 and increased ability to produce interferon gamma (IFN-gamma), and developed into Der p I-specific CD4+ T cell clones showing a T helper type 0 (Th0)- or Th1-, instead of Th2-, like cytokine profile. In contrast, purified protein derivative (PPD)-specific T cell lines derived in the presence of anti-IL-12 antibody exhibited an increased ability to produce IL-4 and developed into PPD-specific CD4+ T cell clones showing a Th0-, instead of Th1-, like profile. The influence of IL-12 on the cytokine secretion profile of Der p I-specific T cell lines was not prevented by addition to lymphocyte bulk cultures of anti-IFN-gamma antibody, but could be at least partially inhibited by the removal from bulk cultures of CD16+ cells. Thus, IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.
引用
收藏
页码:1199 / 1204
页数:6
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