LINKAGE MAPPING OF HUMAN POLYMORPHIC PROTEINS IDENTIFIED BY 2-DIMENSIONAL ELECTROPHORESIS

被引：4

作者：

GOLDMAN, D

OBRIEN, SJ

LUCASDERSE, S

DEAN, M

机构：

[1] FREDERICK CAN RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702

[2] INC DYNCORP,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES,FREDERICK,MD 21702

来源：

GENOMICS | 1991年 / 11卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90010-C

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nineteen polymorphic lymphocyte proteins were previously detected by two-dimensional protein electrophoresis (2DE). In this report, we describe the genetic linkage mapping of six of these polymorphic proteins (PNIA1-PNIA6), the identification by genetic linkage of a seventh (glyoxalase 1 on 6p21), and support for the mapping of an eighth (plastin or LCP1) to near the ESD locus on Chr 13. PNIA1-PNIA6 were assigned, respectively, to 10q26, 16p13.3, 10q, 11p15, 3q, and 19q13. These genetic linkages were achieved by classical linkage analysis of 2DE protein charge polymorphisms to the panel of RFLPs previously typed in nine pedigrees in the Centre D'Etude du Polymorphisme Humain (CEPH) collection. © 1991.

引用

页码：875 / 884

页数：10

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