INDUCTION OF MITOTIC MICRONUCLEI BY THE PYRETHROID INSECTICIDE FENVALERATE IN CULTURED HUMAN-LYMPHOCYTES

被引：37

作者：

SURRALLES, J ^{[1
]}

CARBONELL, E ^{[1
]}

PUIG, M ^{[1
]}

XAMENA, N ^{[1
]}

CREUS, A ^{[1
]}

MARCOS, R ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT GENET & MICROBIOL,UNITAT GENET,E-08193 BARCELONA,SPAIN

来源：

TOXICOLOGY LETTERS | 1990年 / 54卷 / 2-3期

关键词：

FENVALERATE; HUMAN LYMPHOCYTES; MICRONUCLEI;

D O I：

10.1016/0378-4274(90)90178-O

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 mu-g/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.

引用

页码：151 / 155

页数：5

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