EFFECTS OF DILTIAZEM ON HYPERTHERMIA INDUCED SEIZURES IN THE RAT PUP

被引：7

作者：

LAORDEN, ML

CARRILLO, E

MIRALLES, FS

PUIG, MM

机构：

[1] VIRGEN ARRIXACA HOSP,DEPT ANESTHESIOL,MURCIA,SPAIN

[2] NYU MED CTR,NEW YORK,NY 10016

来源：

GENERAL PHARMACOLOGY | 1990年 / 21卷 / 03期

关键词：

D O I：

10.1016/0306-3623(90)90829-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. We studied the effects of a calcium antagonist diltiazem, as well as diazepam and phenytoin on hyperthermia induced seizures in unrestrained 15 day-old rats. 2. 2. Saline injected animals exposed to an ambient temperature of 40°C showed a gradual increase in body temperature reaching a maximum of 42 ± 0.1°C at 50 min. 3. 3. At this time all rats pups had generalized seizures. 4. 4. Similar results were obtained when the animals were pretreated with phenytoin (100% showed seizures). 5. 5. Animals receiving diltiazem had a temperature of 41.5 ± 0.1°C at 90 min of exposure to 40°C environment. 6. 6. However, diltiazem completely prevented seizures. 7. 7. The rats treated with diazepam showed lower temperature than in saline, diltiazem and phenytoin groups and no seizures were observed in this experimental group. © 1990.

引用

页码：313 / 315

页数：3

共 28 条

[1] PREVENTION OF FEBRILE CONVULSIONS WITH DIPROPYLACETATE (DEPAKINE) [J].