ROLE OF PHYTOCHEMICALS (DIET) IN CHEMOPREVENTION OF FAMILIAL ADENOMATOUS POLYPOSIS

Familial Adenomatous Polyposis(FAP) is caused by the mutations of human suppressor APC Gene. Molecular genetic testing confirms the diagnosis, but most of the Indian population cannot use this technology because of limited availability and financial constraints. Clinical findings are also considered for diagnosis of this disease. Once the diagnosis of FAP is done colonoscopic surveillance and polypectomy is done. In severe cases prophylactic colonectomy or partial colonectomy and surveillance of remaining colon is necessary, or it may become malignant. We found taking diet containing ginger (gingerol) and turmeric (curcumin), and avoiding diet containing beta-catenin helps in arresting progress of the disease. However more trials with diet must be undertaken to rely on its benefits.