Electrospinning of biomimetic scaffolds for tissue-engineered vascular grafts: threading the path

被引：31

作者：

Woods, Ian ^{[1
]}

Flanagan, Thomas C. ^{[1
]}

机构：

[1] Univ Coll Dublin, Hlth Sci Ctr, Sch Med & Med Sci, Dublin 4, Ireland

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2014年 / 12卷 / 07期

关键词：

atherosclerosis; congenital heart defect; electrospinning; nanotechnology; tissue engineering; vascular graft;

D O I：

10.1586/14779072.2014.925397

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue-engineered vascular grafts (TEVGs) offer an alternative to synthetic grafts for the surgical treatment of atherosclerosis and congenital heart defects, and may improve graft patency and patient outcomes after implantation. Electrospinning is a versatile manufacturing process for the production of fibrous scaffolds. This review aims to investigate novel approaches undertaken to improve the design of electrospun scaffolds for TEVG development. The review describes how electrospinning can be adapted to produce aligned nanofibrous scaffolds used in vascular tissue engineering, while novel processes for improved performance of such scaffolds are examined and compared to evaluate their effectiveness and potential. By highlighting new drug delivery techniques and porogenic technologies, in addition to analyzing in vitro and in vivo testing of electrospun TEVGs, it is hoped that this review will provide guidance on how the next generation of electrospun vascular graft scaffolds will be designed and tested for the potential improvement of cardiovascular therapies.

引用

页码：815 / 832

页数：18

共 116 条

[1] Autologous blood vessels engineered from peripheral blood sample [J].

Aper, T. ;

Schmidt, A. ;

Duchrow, M. ;

Bruch, H. -P. .

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2007, 33 (01) :33-39

[2] ASSESSMENT OF ELASTIN AND COLLAGEN CONTRIBUTION TO AORTIC ELASTICITY IN CONSCIOUS DOGS [J].

ARMENTANO, RL ;

LEVENSON, J ;

BARRA, JG ;

FISCHER, EIC ;

BREITBART, GJ ;

PICHEL, RH ;

SIMON, A .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (06) :H1870-H1877

[3] Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay [J].

Asefnejad, Azadeh ;

Khorasani, Mohammad Taghi ;

Behnamghader, Aliasghar ;

Farsadzadeh, Babak ;

Bonakdar, Shahin .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 :2375-2384

[4] The effect of nanofiber alignment on the maturation of engineered meniscus constructs [J].

Baker, Brendon M. ;

Mauck, Robert L. .

BIOMATERIALS, 2007, 28 (11) :1967-1977

[5] Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation [J].

Baker, Brendon M. ;

Shah, Roshan P. ;

Silverstein, Amy M. ;

Esterhai, John L. ;

Burdick, Jason A. ;

Mauck, Robert L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (35) :14176-14181

[6] The influence of an aligned nanofibrous topography on human mesenchymal stem cell fibrochondrogenesis [J].

Baker, Brendon M. ;

Nathan, Ashwin S. ;

Gee, Albert O. ;

Mauck, Robert L. .

BIOMATERIALS, 2010, 31 (24) :6190-6200

[7] Effect of Fiber Diameter and Alignment of Electrospun Polyurethane Meshes on Mesenchymal Progenitor Cells [J].

Bashur, Chris A. ;

Shaffer, Robyn D. ;

Dahlgren, Linda A. ;

Guelcher, Scott A. ;

Goldstein, Aaron S. .

TISSUE ENGINEERING PART A, 2009, 15 (09) :2435-2445

[8] Electrospinning: A fascinating fiber fabrication technique [J].

Bhardwaj, Nandana ;

Kundu, Subhas C. .

BIOTECHNOLOGY ADVANCES, 2010, 28 (03) :325-347

[9] Low-temperature electrospun silk scaffold for in vitro mucosal modeling [J].

Bulysheva, Anna A. ;

Bowlin, Gary L. ;

Klingelhutz, Aloysius J. ;

Yeudall, W. Andrew .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A (03) :757-767

[10]

Bunning TJ, 1993, SILK POLYM, P353

← 1 2 3 4 5 6 7 8 9 10 →