METABOLIC RESPONSE TO TACRINE (THA) AND PHYSOSTIGMINE IN THE AGED RAT-BRAIN

被引:9
作者
BASSANT, MH
JAZATPOINDESSOUS, F
机构
[1] INSERM U161, Paris
[2] INSERM U 161, 75014 Paris
关键词
TETRAHYDROAMINOACRIDINE; PHYSOSTIGMINE; ACETYLCHOLINE; CEREBRAL GLUCOSE UTILIZATION; AGING;
D O I
10.1038/jcbfm.1995.136
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of the centrally acting anticholinesterases tacrine (tetrahydroaminoacridine, THA) and physostigmine (PHY), on local cerebral glucose utilization (LCGU) have been studied in 27-month-old rats, using the autoradiographic [C-14]deoxyglucose technique. THA (10 mg/kg i.p.) increased LCGU significantly in 13 of the 54 regions studied (24%) including insular, parietal, temporal, and retrosplenial cortices, septohippocampal system, thalamus, lateral habenula, and superior colliculus. In these regions, the average THA-induced increase in LCGU was 24% above control. The whole brain mean LCGU was not significantly increased. PHY (0.5 mg/kg) increased LCGU in 18% of the regions (average elevation, 23%), The whole brain mean LCGU increased by 7% (p < 0.05). The regional distributions of THA- and PHY-induced increases in LCGU were extremely similar and overlapped the distribution of the M(2) muscarinic receptors and that of acetylcholinesterase activity, suggesting that the major effects of THA and PHY on LCGU result from their anticholinesterase action, As compared to those of 3-month-old rats, both the number of regions affected and the amplitude of the metabolic activation were significantly less in aged rats. However, the drugs were still active in old rats and compensated for the age-related hypometabolism in some brain areas.
引用
收藏
页码:1093 / 1102
页数:10
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