LACK OF EFFECT OF TRANSIENT ISCHEMIA ON UBIQUITIN CONJUGATION

被引：6

作者：

KAMIKUBO, T ^{[1
]}

HAYASHI, T ^{[1
]}

OHKAWA, K ^{[1
]}

机构：

[1] JIKEI UNIV,SCH MED,DEPT BIOCHEM,MINATO KU,TOKYO 105,JAPAN

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 04期

关键词：

UBIQUITIN; ISCHEMIA; CORTEX; HIPPOCAMPUS; GERBIL;

D O I：

10.1007/BF00973092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitin-conjugating activities in the soluble fractions of gerbil cortex and hippocampus following transient ischemia were examined in vitro. Ten minutes of ischemia did not affect the ubiquitination of heat-denatured lysozyme both in the cortex and in the hippocampus. No reduction of the conjugating activities following ischemia was also confirmed using the partially purified ubiquitin conjugating enzymes from the cortex. These results indicate that protein ubiquitination might not be impaired following transient ischemia.

引用

页码：391 / 394

页数：4

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