ONE-STEP CONVERSION OF AMINO-ACIDS INTO N-MENTHYLOXYCARBONYL ALKYL ESTER DERIVATIVES FOR CHIRAL GAS-CHROMATOGRAPHY

Amino acids dissolved in aqueous methanol (or ethanol) and treated with optically active menthyl chloroformate were converted into N-menthyloxycarbonyl methyl (or ethyl) ester derivatives within a few minutes at room temperature. The obtained diastereomeric derivatives, with the exception of arginine and histidine, had suitable gas chromatographic properties allowing enantiomeric analysis of a large number of proteinogenic and synthetic amino acids. © 1993 Academic Press, Inc.