OXYFUNCTIONALIZATION OF STEROIDS BY DIOXIRANES - SITE AND STEREOSELECTIVE C-14 AND C-17 HYDROXYLATION OF PREGNANE AND ANDROSTANE STEROIDS

被引：30

作者：

BOVICELLI, P

LUPATTELLI, P

FIORINI, V

MINCIONE, E

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM,CNR,CTR CHIM SOSTANZE ORGAN NAT,P A MORO 5,I-00185 ROME,ITALY

[2] UNIV TUSCIA,DABAC,I-01100 VITERBO,ITALY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)61739-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimethyldioxirane showed to be site and stereoselective in the C-H oxygen insertion of C-14 and C-17 positions of pregnane and androstane steroids. Fine steric control and evidence for the influence of the carbonyl group on the dioxirane reactivity are reported.

引用

页码：6103 / 6104

页数：2

共 5 条

[1]

BACH RD, IN PRESS

[2] A HIGHLY REGIOSELECTIVE AND STEREOSELECTIVE-C5 OXYFUNCTIONALIZATION OF COPROSTANE STEROIDS BY DIOXIRANES - AN IMPROVED ACCESS TO PROGESTOGEN AND ANDROGEN HORMONES [J].