Significance of data analysis in the quality control of prenatal screening for Down syndrome

被引：7
|
作者：
Li, Yahong [1 ]
Zhang, Xiaojuan [1 ]
Hong, Dongyang [1 ]
Guan, Xianwei [1 ]
Lv, Shaolei [2 ]
Sun, Yun [1 ]
Jiang, Tao [1 ]
机构：
[1] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Ctr Prenatal Diag, Affiliated Obstet & Gynecol Hosp, 123 Tianfei Rd, Nanjing 210004, Jiangsu, Peoples R China
[2] Zhejiang Biosan Biochem Technol Co Ltd, Hangzhou 310000, Zhejiang, Peoples R China
来源：
BIOMEDICAL REPORTS | 2018年 / 8卷 / 05期
基金：
中国国家自然科学基金;
关键词：
quality control; prenatal screening; Down syndrome;
D O I：
10.3892/br.2018.1078
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Dual detection of alpha-fetoprotein (AFP) and free beta-human chorionic gonadotropin (beta-HCG) is a common screening method for Down syndrome in the second trimester and its efficacy is assessed by false-positive rate (FPR). The present study aimed to investigate the effects of the bias in median multiple of the median (mMoM) values of AFP and free beta-HCG on FPR. The bias in mMoM values of AFP and free beta-HCG and the bias in mMoM values under different gestational ages and weight groups were analyzed. Median equations were adjusted, and medians in LifeCycle software were replaced by local medians. Following two adjustments of the median equations, all indices including FPR, mMoM values of markers and mMoM values under different gestational ages and weight groups generally reached an ideal state. In conclusion, abnormal bias in mMoM values may prompt aberrant application of median equations, and regular monitoring of these indicators may be important for quality control in prenatal screening.
引用
收藏
页码：447 / 453
页数：7
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