NEUROSTEROIDS IN THE BRAIN OF HANDLING-HABITUATED AND NAIVE RATS - EFFECT OF CO2 INHALATION

被引：66
作者：
BARBACCIA, ML
ROSCETTI, G
TRABUCCHI, M
CUCCHEDDU, T
CONCAS, A
BIGGIO, G
机构：
[1] UNIV ROMA TOR VERGATA,DIPARTIMENTO MED SPERIMENTALE,I-00133 ROME,ITALY
[2] UNIV CAGLIARI,DIPARTIMENTO BIOL SPERIMENTALE,I-09123 CAGLIARI,ITALY
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 261卷 / 03期
关键词：
NEUROSTEROID; STRESS; HANDLING; CO2; BRAIN; RAT;
D O I：
10.1016/0014-2999(94)90123-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In rats habituated to the manipulation that precedes killing (handling-habituated) the cerebral cortical concentrations of pregnenolone and progesterone were significantly lower (-57% and -69%, respectively) than in naive animals. An acute stress, induced by CO2 inhalation, elicited a marked increase in the concentrations of pregnenolone, progesterone and deoxycorticosterone in the brain cortex and hippocampus of handling-habituated rats. An accepted stress, such as foot shock, also enhanced the brain cortical levels of pregnenolone, progesterone and deoxycorticosterone in handling-habituated rats. These data show that the rat brain cortical and hippocampal steroid content is related to the 'emotional state' of the animal.
引用
收藏
页码：317 / 320
页数：4
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