CLONING AND SEQUENCE-ANALYSIS OF A FULL-LENGTH CDNA-ENCODING HUMAN MITOCHONDRIAL 3-OXOACYL-COA THIOLASE

被引：23

作者：

ABE, H

OHTAKE, A

YAMAMOTO, S

SATOH, Y

TAKAYANAGI, M

AMAYA, Y

TAKIGUCHI, M

SAKURABA, H

SUZUKI, Y

MORI, M

NIIMI, H

机构：

[1] CHIBA UNIV,SCH MED,DEPT PEDIAT,1-8-1 INOHANA,CHUO KU,CHIBA 260,JAPAN

[2] TOKYO METROPOLITAN INST MED SCI,DEPT CLIN GENET,TOKYO 113,JAPAN

[3] KUMAMOTO UNIV,SCH MED,DEPT MOLEC GENET,KUMAMOTO 860,JAPAN

[4] CHIBA CHILDRENS HOSP,DIV METAB,CHIBA,JAPAN

[5] SHIMOSHIZU NATL HOSP & SANITORIUM,DEPT PEDIAT,DEPT PEDIAT,YOTSUKAIDO,CHIBA,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1216卷 / 02期

关键词：

FATTY ACID OXIDATION; MITOCHONDRIAL ENZYME; NON-CLEAVABLE SIGNAL; SEQUENCE HOMOLOGY; REYE SYNDROME; SUDDEN INFANT DEATH; (HUMAN);

D O I：

10.1016/0167-4781(93)90160-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNA sequence of human mitochondrial 3-oxoacyl-CoA thiolase was determined. The nucleotide sequence contains an open reading frame of 1191 base pairs and encodes an amino acid sequence of 397 residues which exhibits 86.6% homology with that of the rat enzyme. Northern blot analysis gave a single mRNA species of 1.6 kb in the human liver, fibroblasts and intercostal muscle.

引用

页码：304 / 306

页数：3

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