AN ANTILEISHMANIAL CHALCONE FROM CHINESE LICORICE ROOTS

被引：34

作者：

CHRISTENSEN, SB

MING, C

ANDERSEN, L

HJORNE, U

OLSEN, CE

CORNETT, C

THEANDER, TG

KHARAZMI, A

机构：

[1] UNIV COPENHAGEN HOSP, DEPT CLIN MICROBIOL, DK-2200 COPENHAGEN N, DENMARK

[2] STATENS SERUM INST, DK-2300 COPENHAGEN S, DENMARK

[3] ROYAL VET & AGR UNIV, DEPT CHEM, DK-1871 FREDERIKSBERG, DENMARK

[4] UNIV COPENHAGEN, INST MED MICROBIOL & IMMUNOL, CTR MED PARASITOL, DK-2200 COPENHAGEN N, DENMARK

来源：

PLANTA MEDICA | 1994年 / 60卷 / 02期

关键词：

LEISHMANIA; GLYCYRRHIZA; FABACEAE; CHALCONES; ANTILEISHMANIAL ACTIVITY;

D O I：

10.1055/s-2006-959431

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4-hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(2,2-dimethyl-2-butenyl-8-hydroxy-2H-benzopyran-6-yl)-2-propen-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

引用

页码：121 / 123

页数：3

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