INHIBITION BY GLYCYRRHETINIC ACID OF RAT-TISSUE 11-BETA-HYDROXYSTEROID DEHYDROGENASE INVIVO

被引：25
|
作者：
MARANDICI, A [1 ]
MONDER, C [1 ]
机构：
[1] POPULAT COUNCIL, 1230 YORK AVE, NEW YORK, NY 10021 USA
来源：
STEROIDS | 1993年 / 58卷 / 04期
关键词：
RAT LIVER 11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLYCYRRHETINIC ACID; ENZYME INHIBITION; CORTICOSTERONE; INVIVO STUDIES; STEROIDS;
D O I：
10.1016/0039-128X(93)90062-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inhibition of 11beta-hydroxysteroid dehydrogenase (11-HSD) in the major organs of the rat by the inhibitor glycyrrhetinic acid (a component of licorice) was investigated. The inhibitor decreased 11-HSD levels in most organs after intraperitoneal injection. The effect was dose dependent, was maximally effective 3 hours after administration, and was completely reversed at 24 hours. The magnitude and patterns of effectiveness differed between tissues. It was concluded that the inhibition of 11-HSD by glycyrrhetinic acid is not restricted to one or a few organs, but is broadly based.
引用
收藏
页码：153 / 156
页数：4
相关论文
共 50 条
  • [31] LOCALIZATION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
    EDWARDS, CRW
    BURT, D
    MCINTYRE, MA
    DEKLOET, ER
    STEWART, PM
    BRETT, L
    SUTANTO, WS
    MONDER, C
    LANCET, 1988, 2 (8618): : 986 - 989
  • [32] FIRST SYMPOSIUM ON 11-BETA-HYDROXYSTEROID DEHYDROGENASE - FOREWORD
    FREY, F
    FUNDER, J
    MONDER, C
    STEROIDS, 1994, 59 (02) : 65 - 65
  • [33] 11-BETA-HYDROXYSTEROID DEHYDROGENASE - ON SEVERAL ROADS TO HYPERTENSION
    SECKL, JR
    BROWN, RW
    JOURNAL OF HYPERTENSION, 1994, 12 (02) : 105 - 112
  • [34] GENETIC-ANALYSIS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE
    WHITE, PC
    OBEID, J
    AGARWAL, AK
    TANNIN, GM
    NIKKILA, H
    STEROIDS, 1994, 59 (02) : 111 - 115
  • [35] GRAPEFRUIT JUICE INHIBITS 11-BETA-HYDROXYSTEROID DEHYDROGENASE
    LEE, YS
    LORENZO, BJ
    REIDENBERG, MM
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 55 (02) : 139 - 139
  • [36] FUNCTIONAL-STUDIES OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE
    WHITE, PC
    MUNE, T
    AGARWAL, AK
    STEROIDS, 1995, 60 (01) : 65 - 68
  • [37] 11-BETA-HYDROXYSTEROID DEHYDROGENASE - WHY IS IT IMPORTANT FOR THE NEPHROLOGIST
    ESCHER, G
    FREY, BM
    FREY, FJ
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1995, 10 (09) : 1506 - 1509
  • [38] KINETIC-STUDIES ON RAT-LIVER 11-BETA-HYDROXYSTEROID DEHYDROGENASE
    MONDER, C
    LAKSHMI, V
    MIROFF, Y
    BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1115 (01) : 23 - 29
  • [39] ENDOGENOUS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN HYPERTENSION
    WALKER, BR
    AGGARWAL, I
    STEWART, PM
    PADFIELD, PL
    EDWARDS, CRW
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (02): : 529 - 533
  • [40] DIFFERENTIAL INHIBITION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE BY CARBENOXOLONE IN RAT-BRAIN REGIONS AND PERIPHERAL-TISSUES
    JELLINCK, PH
    MONDER, C
    MCEWEN, BS
    SAKAI, RR
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 46 (02): : 209 - 213
12345