INHIBITION BY GLYCYRRHETINIC ACID OF RAT-TISSUE 11-BETA-HYDROXYSTEROID DEHYDROGENASE INVIVO

被引：25

作者：

MARANDICI, A ^{[1
]}

MONDER, C ^{[1
]}

机构：

[1] POPULAT COUNCIL, 1230 YORK AVE, NEW YORK, NY 10021 USA

来源：

STEROIDS | 1993年 / 58卷 / 04期

关键词：

RAT LIVER 11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLYCYRRHETINIC ACID; ENZYME INHIBITION; CORTICOSTERONE; INVIVO STUDIES; STEROIDS;

D O I：

10.1016/0039-128X(93)90062-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibition of 11beta-hydroxysteroid dehydrogenase (11-HSD) in the major organs of the rat by the inhibitor glycyrrhetinic acid (a component of licorice) was investigated. The inhibitor decreased 11-HSD levels in most organs after intraperitoneal injection. The effect was dose dependent, was maximally effective 3 hours after administration, and was completely reversed at 24 hours. The magnitude and patterns of effectiveness differed between tissues. It was concluded that the inhibition of 11-HSD by glycyrrhetinic acid is not restricted to one or a few organs, but is broadly based.

引用

页码：153 / 156

页数：4

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