VERSATILE COMPLEX-FORMATION KINETICS OBSERVED FOR THE REACTIONS OF A MODEL CIS-BIS(AMINE)PALLADIUM(II) COMPLEX WITH DNA NUCLEOSIDES AND NUCLEOTIDES

被引：28

作者：

SUVACHITTANONT, S

HOHMANN, H

VANELDIK, R

REEDIJK, J

机构：

[1] UNIV WITTEN,INST INORGAN CHEM,STOCKUMER STR 10,D-58448 WITTEN,GERMANY

[2] LEIDEN UNIV,GORLAEUS LABS,DEPT CHEM,2300 RA LEIDEN,NETHERLANDS

来源：

INORGANIC CHEMISTRY | 1993年 / 32卷 / 21期

关键词：

D O I：

10.1021/ic00073a013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The complex-formation reactions of Pd(Et4en)Cl2 (Et4en = N,N,N',N'-tetraethylethylenediamine) with inosine and inosine 5'-monophosphate were studied as a function of nucleophile and chloride concentration. Two consecutive reaction steps could be observed under all experimental conditions. A detailed kinetic analysis revealed that [Pd(Et4en)(Cl)H2O]+ is the reactive species in the first complex-formation step, for which a steady-state approximation can be used. In the case of the second step, a rapid preequilibrium [Pd(Et4en)(Nu)Cl]+ + H2O half arrow right over half arrow left [Pd(Et4en)(Nu)H2O]2+ + Cl- is followed by rate-determining substitution of the aqua complex to produce the 1:2 product species. The complex-formation reaction of [Pd(Et4en)(H2O)2]2+ with the dinucleotide d(GpG) was studied as a function of nucleophile concentration, temperature and pressure. Two consecutive reaction steps were observed in which the first exhibits a dependence on the d(GpG) concentration and the second is concentration independent. The negative DELTAS(double dagger) and DELTAV(double dagger) values for the first reaction step support an associative complex-formation reaction, which is followed by the slower ring-closure reaction.

引用

页码：4544 / 4548

页数：5

共 40 条

[31] Electron paramagnetic resonance, kinetics of formation and decomposition studies of (Bis(hydroxyethyl)amino-tris(hydroxymethyl)-methane)oxochromate(V): A model chromium(V) complex for DNA damage studies
Fonkeng, BS
Moghaddas, S
Bose, RN
JOURNAL OF INORGANIC BIOCHEMISTRY, 1998, 72 (3-4) : 163 - 171
[32] MICELLAR EFFECTS UPON THE REACTIONS OF COMPLEX-IONS IN SOLUTION .4. KINETICS OF AQUATION AND BASE HYDROLYSIS OF SOME CIS-(CHLORO)(AMINE)BIS(ETHYLENEDIAMINE)COBALT(III) COMPLEXES IN THE PRESENCE OF NEUTRAL AND ANIONIC SURFACTANTS IN AN AQUEOUS-MEDIUM
DASH, AC
PRUSTI, J
PRADHAN, J
DAS, PK
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1990, 86 (03): : 507 - 510
[33] Equilibrium investigation of complex formation reactions involving copper(II), nitrilo-tris(methyl phosphonic acid) and amino acids, peptides or DNA constitutents. The kinetics, mechanism and correlation of rates with complex stability for metal ion promoted hydrolysis of glycine methyl ester
El-Sherif, Ahmed A.
Shoukry, Mohamed M.
JOURNAL OF COORDINATION CHEMISTRY, 2006, 59 (14) : 1541 - 1556
[34] STEREOSELECTIVITY IN REACTIONS OF METAL-COMPLEXES .11. 2,6-BIS(PYRROLIDIN-2-YL)PYRIDINE - SYNTHESIS AND RESOLUTION OF THE MESO AND THE OPTICALLY-ACTIVE ISOMERS - COMPLEX-FORMATION WITH COPPER(II) ION IN AQUEOUS-SOLUTION
BERNAUER, K
GRETILLAT, F
HELVETICA CHIMICA ACTA, 1989, 72 (03) : 477 - 481
[35] Palladium-assisted formation of carbon-carbon bonds .4. Synthesis and reactivity of a water-soluble (2,3,4-trimethoxy-6-(ethoxymethyl)phenyl)palladium(II) complex. Reactions with alkynes of its derivatives: Further insight into the pathway of formation of highly functionalized organic spirocycles and X-ray structures of model intermediates
Vicente, J
Abad, JA
FernandezdeBobadilla, R
Jones, PG
de Arellano, MCR
ORGANOMETALLICS, 1996, 15 (01) : 24 - 34
[36] Kinetics and mechanism of the formation of (1,8)bis(2-hydroxybenzamido)3,6-diazaoctaneiron(III) and its reactions with thiocyanate, azide, acetate, sulfur(IV) and ascorbic acid in solution, and the synthesis and characterization of a novel oxo bridged diiron(III) complex. The role of phenol–amide–amine coordination
Suprava Nayak
Anadi C. Dash
Transition Metal Chemistry, 2006, 31 : 813 - 828
[37] Kinetics and mechanism of the formation of (1,8)bis(2-hydroxybenzamido)3,6-diazaoctaneiron(III) and its reactions with thiocyanate, azide, acetate, sulfur(IV) and ascorbic acid in solution, and the synthesis and characterization of a novel oxo bridged diiron(III) complex. The role of phenol–amide–amine coordination
Suprava Nayak
Anadi C. Dash
Transition Metal Chemistry, 2006, 31 : 1098 - 1098
[38] Kinetics and mechanism of the formation of (1,8)bis(2-hydroxybenzamido)3,6-diazaoctaneiron(III) and its reactions with thiocyanate, azide, acetate, sulfur(IV) and ascorbic acid in solution, and the synthesis and characterization of a novel oxo bridged diiron(III) complex.: The role of phenol-amide-amine coordination
Nayak, Suprava
Dash, Anadi C.
TRANSITION METAL CHEMISTRY, 2006, 31 (06) : 813 - 828
[39] Kinetics and mechanism of the formation of (1,8)bis(2-hydroxybenzamido)3,6-diazaoctaneiron(III) and its reactions with thiocyanate, azide, acetate, sulfur(IV) and ascorbic acid in solution, and the synthesis and characterization of a novel oxo bridged diiron(III) complex.: The role of phenol-amide-amine coordination (vol 31, pg 813, 2006)
Nayak, Suprava
Dash, Anadi C.
TRANSITION METAL CHEMISTRY, 2006, 31 (08) : 1098 - 1098
[40] Reactivity of a cationic square-planar palladium(II) chloro complex containing bis[2-(diphenylphosphino)ethyl]amine:: chloro substitutions by anionic ligands and formation of neutral digold(I) compounds possessing linear PAuX fragments.: The X-Ray crystal structure of Au2[Ph2P(CH2)2N(NO)(CH2)2PPh2]Cl2
García-Seijo, MI
Habtemariam, A
Parsons, S
Gould, RO
García-Fernández, ME
NEW JOURNAL OF CHEMISTRY, 2002, 26 (05) : 636 - 644

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