WHY DO GENES HAVE INTRONS

被引:29
作者
DIBB, NJ
机构
[1] Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12 ONN, Du Cane Road
基金
英国医学研究理事会;
关键词
INTRON ORIGIN; ALTERNATIVE SPLICING; EVOLUTION;
D O I
10.1016/0014-5793(93)81429-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review outlines some of the models that have been proposed to explain why genes have introns and then explores the possibility that alternative splicing might be the cause rather than a consequence of split genes.
引用
收藏
页码:135 / 139
页数:5
相关论文
共 40 条
[1]   GENERATION OF PROTEIN ISOFORM DIVERSITY BY ALTERNATIVE SPLICING - MECHANISTIC AND BIOLOGICAL IMPLICATIONS [J].
ANDREADIS, A ;
GALLEGO, ME ;
NADALGINARD, B .
ANNUAL REVIEW OF CELL BIOLOGY, 1987, 3 :207-242
[2]   REVERSE SELF-SPLICING OF GROUP-II INTRON RNAS INVITRO [J].
AUGUSTIN, S ;
MULLER, MW ;
SCHWEYEN, RJ .
NATURE, 1990, 343 (6256) :383-386
[3]   PROSITE - A DICTIONARY OF SITES AND PATTERNS IN PROTEINS [J].
BAIROCH, A .
NUCLEIC ACIDS RESEARCH, 1992, 20 :2013-2018
[4]   EXONS - PRESENT FROM THE BEGINNING [J].
BLAKE, C .
NATURE, 1983, 306 (5943) :535-537
[5]   COMPARISON OF INTRON-DEPENDENT AND INTRON-INDEPENDENT GENE-EXPRESSION [J].
BUCHMAN, AR ;
BERG, P .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (10) :4395-4405
[6]   INTRON PHYLOGENY - A NEW HYPOTHESIS [J].
CAVALIERSMITH, T .
TRENDS IN GENETICS, 1991, 7 (05) :145-148
[7]   THE GENERALITY OF SELF-SPLICING RNA - RELATIONSHIP TO NUCLEAR MESSENGER-RNA SPLICING [J].
CECH, TR .
CELL, 1986, 44 (02) :207-210
[8]   SPECULATIONS ON THE EARLY COURSE OF EVOLUTION [J].
DARNELL, JE ;
DOOLITTLE, WF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) :1271-1275
[9]   EVIDENCE THAT INTRONS AROSE AT PROTO-SPLICE SITES [J].
DIBB, NJ ;
NEWMAN, AJ .
EMBO JOURNAL, 1989, 8 (07) :2015-2021
[10]   PROTO-SPLICE SITE MODEL OF INTRON ORIGIN [J].
DIBB, NJ .
JOURNAL OF THEORETICAL BIOLOGY, 1991, 151 (03) :405-416