ANTIBODY DEPENDENT CELL-MEDIATED CYTOTOXICITY ON HUMAN CERVICAL-CARCINOMA CELL-LINE, ME-180, WITH HUMAN MONOCLONAL-ANTIBODY

被引：4

作者：

OSUMI, K

NAGAO, J

YUASA, H

FUJIMOTO, H

HAGIWARA, H

KODERA, Y

OHNO, R

机构：

[1] MITSUBISHI PETROCHEM CO LTD,CENT RES LAB,IBARAKI 30003,JAPAN

[2] HAGIWARA INST HLTH,KASAISHI,HYOGO 67901,JAPAN

[3] NAGOYA FIRST RED CROSS HOSP,NAKAMURA KU,NAGOYA 466,JAPAN

[4] NAGOYA UNIV,SCH MED,INTERNAL MED 1,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

CANCER LETTERS | 1992年 / 62卷 / 02期

关键词：

HUMAN MONOCLONAL ANTIBODY; ANTIBODY DEPENDENT CELL-MEDIATED CYTOTOXICITY; ANTICANCER ANTIBODY; TUMOR IMMUNITY; CYTOTOXICITY; EFFECTOR CELL;

D O I：

10.1016/0304-3835(92)90190-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A human monoclonal antibody (MCA), CLN-IgG, showed cytotoxic effect in vitro against the cervical carcinoma cell line, ME-180, by antibody dependent cell-mediated cytotoxicity (ADCC). To determine which fractions of cells in peripheral blood lymphocyte (PBL) mediate ADCC, PBL were separated with nylon wool column and sheep red blood cells (SRBC). Both adherent cells (monocyte) and non-T, non-B cells showed cytotoxicity by ADCC. Human non-T, non-B cells showed higher cytotoxic activity against ME-180 cells than monocytes. Furthermore murine effector cells were less effective in ADCC than human effector cells with human MCA.

引用

页码：179 / 183

页数：5

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