NUCLEOTIDE-SEQUENCE AND CODING STRATEGY OF THE UUKUNIEMI VIRUS-L RNA SEGMENT

被引：28

作者：

ELLIOTT, RM ^{[1
]}

DUNN, E ^{[1
]}

SIMONS, JF ^{[1
]}

PETTERSSON, RF ^{[1
]}

机构：

[1] LUDWIG INST CANC RES, STOCKHOLM BRANCH, S-10401 STOCKHOLM, SWEDEN

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-7-1745

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The complete nucleotide sequence of the L RNA segment of Uukuniemi virus has been determined from cloned cDNA. The L RNA is 6423 nucleotides in length, and is of negative polarity. The viral-complementary RNA contains a single large open reading frame of 2104 codons which corresponds to the L protein (M(r) 241039). Comparison with the L protein sequences of other members of the Bunyaviridae showed homology with the Rift Valley fever phlebovirus L protein (38% amino acid identity), but no detectable similarity with bunyavirus, hantavirus or tospovirus L proteins. These data lend further support for the recent reclassification of uukuviruses and phleboviruses into the same genus, Phlebovirus, in the family Bunyaviridae. The L RNA sequence completes the determination of the Uukuniemi virus genome: since the M RNA segment is 3229 and the S RNA segment 1720 nucleotides, the whole genome comprises 11 372 nucleotides.

引用

页码：1745 / 1752

页数：8

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