EARLY POSTOPERATIVE CHEMOTHERAPY FOLLOWING NONCURATIVE RESECTION FOR PATIENTS WITH ADVANCED GASTRIC-CANCER

被引：23
作者：
MAEHARA, Y
SUGIMACHI, K
AKAGI, M
KAKEGAWA, T
SHIMAZU, H
TOMITA, M
机构：
[1] KUMAMOTO UNIV,FAC MED,DEPT SURG 2,KUMAMOTO 860,JAPAN
[2] KURUME UNIV,FAC MED,DEPT SURG 1,KURUME,FUKUOKA 830,JAPAN
[3] KAGOSHIMA UNIV,FAC MED,DEPT SURG 1,KAGOSHIMA 890,JAPAN
[4] NAGASAKI UNIV,FAC MED,DEPT SURG 1,NAGASAKI 852,JAPAN
来源：
BRITISH JOURNAL OF CANCER | 1992年 / 65卷 / 03期
关键词：
D O I：
10.1038/bjc.1992.84
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We studied the effect of early postoperative chemotherapy, including 5-fluorouracil (5-FU) for 5 days for patients with gastric cancer following noncurative resection. The study was prospectively randomised and controlled, and 162 (87.1%) of 186 were eligible candidates for statistical assessment. Patients randomised to group A received therapy that is used widely to treat patients with gastric cancer in Japan; mitomycin C (MMC), OK-432, UFT and PSK. Patients randomised to group B received the same drugs given to group A plus 5-FU bolus injections for 5 days, beginning on postoperative day 2. There were no differences in prognostic factors and doses of the drugs prescribed, except for 5-FU. There was no difference in the toxicity rate between the groups. Generalised Wilcoxon test revealed a P value of 0.169, and the 50% survival rate improved 1.4-fold in patients with gastric cancer treated with early postoperative chemotherapy of MMC, OK-432 plus 5-FU injection.
引用
收藏
页码：413 / 416
页数：4
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