Human Leukocyte Antigen-G (HLA-G) and Heat-Shock Protein-70 (Hsp-70) Expression on Intra Uterine Growth Retardation

Intra uterine growth retardation (IUGR) is one of the leading causes of higher morbidity and mortality in perinatal. Immune maladaptation affects trophoblast invasion and spiralis arteria remodeling that will cause placental tissue hypoxia. This research aimed to analyze human leukocyte antigen-G (HLA-G) and heat-shock protein-70 (Hsp70) expression on the IUGR trophoblast and normal pregnancy, by applying analytical observational method and cross sectional approach. This research was conducted at the Obstetric and Gynecology Department of Dr. Moewardi Hospital Surakarta from November to December 2011. The total samples were 30, divided into two groups. There were 15 samples trophoblast on IUGR and 15 samples trophoblast from normal pregnancy. All samples were tested for HLA-G and Hsp-70 using immunohistochemistry. The data were analyzed by using t-test. The mean of HLA-G expression on the IUGR groups was 32.42 +/- 8.90 and on the normal pregnancy groups was 43.92 +/- 14.91 (p= 0.016). Heat-shock protein70 expression on the IUGR groups was 2.4355+ 0.26647 and on the normal pregnancy groups was 1.5920+ 0.17142 with p= 0.008. In conclusion, in IUGR, the HLA-G expression is lower and the Hsp-70 expression is higher than in normal pregnancy.