Computational Modelling for Efficient Transdentinal Drug Delivery

被引：2

作者：

Passos, Agathoklis D. ^{[1
]}

Tziafas, Dimitris ^{[2
]}

Mouza, Aikaterini A. ^{[1
]}

Paras, Spiros V. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem Engn, Thessaloniki 54124, Greece

[2] DHCC Dubai, Hamdan Bin Mohamed Coll Dent Med, Dubai, U Arab Emirates

来源：

FLUIDS | 2018年 / 3卷 / 01期

关键词：

drug delivery; dentine; diffusion; bio-active molecules; CFD; mu-LIF; microfluidics;

D O I：

10.3390/fluids3010004

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

This work deals with the numerical investigation of the delivery of potential therapeutic agents through dentinal discs (i.e., a cylindrical segment of the dentinal tissue) towards the dentin-pulp junction. The aim is to assess the main key features (i.e., molecular size, initial concentration, consumption rate, disc porosity and thickness) that affect the delivery of therapeutic substances to the dental pulp and consequently to define the necessary quantitative and qualitative issues related to a specific agent before its potential application in clinical practice. The computational fluid dynamics (CFD) code used for the numerical study is validated with relevant experimental data obtained using micro Laser Induced Fluorescence (mu-LIF) a non-intrusive optical measuring technique. As the phenomenon is diffusion dominated and strongly dependent on the molecular size, the time needed for the concentration of released molecules to attain a required value can be controlled by their initial concentration. Finally, a model is proposed which, given the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tissue along with the aforementioned key design parameters, is able to estimate the initial concentration to be imposed and vice versa.

引用

页数：17

共 33 条

[21]

Pashley D H, 1992, Proc Finn Dent Soc, V88 Suppl 1, P31

[22]

Pashley D. H, 1990, DENTIN PERMEABILITY

[23] THE EFFECTS OF OUTWARD FORCED CONVECTIVE FLOW ON INWARD DIFFUSION IN HUMAN DENTIN IN-VITRO [J].

PASHLEY, DH ;

MATTHEWS, WG .

ARCHIVES OF ORAL BIOLOGY, 1993, 38 (07) :577-582

[24] Study of the transdentinal diffusion of bioactive molecules [J].

Passos, A. D. ;

Tziafas, D. ;

Mouza, A. A. ;

Paras, S. V. .

MEDICAL ENGINEERING & PHYSICS, 2016, 38 (12) :1408-1415

[25] THE EQUIVALENT CHANNEL MODEL FOR PERMEABILITY AND RESISTIVITY IN FLUID-SATURATED ROCK - A RE-APPRAISAL [J].

PATERSON, MS .

MECHANICS OF MATERIALS, 1983, 2 (04) :345-352

[26] TRANSDENTINAL STIMULATION OF REPARATIVE DENTIN FORMATION BY OSTEOGENIC PROTEIN-1 IN MONKEYS [J].

RUTHERFORD, B ;

SPANGBERG, L ;

TUCKER, M ;

CHARETTE, M .

ARCHIVES OF ORAL BIOLOGY, 1995, 40 (07) :681-683

[27] Whole field measurement of temperature in water using two-color laser induced fluorescence [J].

Sakakibara, J ;

Adrian, RJ .

EXPERIMENTS IN FLUIDS, 1999, 26 (1-2) :7-15

[28] Transdentinal stimulation of reactionary dentinogenesis in ferrets by dentine matrix components [J].

Smith, AJ ;

Tobias, RS ;

Murray, PE .

JOURNAL OF DENTISTRY, 2001, 29 (05) :341-346

[29]

Smith Anthony J, 2003, J Dent Educ, V67, P678

[30] Study of a micro-structured PHE for the thermal management of a fuel cell [J].

Stogiannis, Ioannis A. ;

Mouza, Aikaterini A. ;

Paras, Spiros V. .

APPLIED THERMAL ENGINEERING, 2013, 59 (1-2) :717-724

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