SYNTHESIS OF 5-SUBSTITUTE-3-ARYL-2H,3H-BENZO/NAPHTHO-[1,2-F] [1,3,4]-OXADIAZEPIN-2-THIONES AS POTENTIAL TRANQUILIZERS AND ANTICONVULSANTS

It has been reported that certain synthetic analgesics, sedatives, hypnotics, tranquillizers and anticonvulsants are associated with the presence of carboxamido and carboximido GRAPHICS and carboximido GRAPHICS groups in these drugs. Biosteric replacement of carboxamido group GRAPHICS with thioamido function has successfully resulted in many more potent but relatively short acting and less. toxic drugs with similar muscle relaxing properties. In the present study a series of compounds containing benz/nepth oxadiazepine systems has been synthesised through cyclisation with thiophosgene of substituted arylhydrazones obtained by condensation of 2-hydroxyarylaldehydes/ketones with substituted arylhydrazines. The synthesised compounds are cyclic thiocarbamates and may prove to be effective insecticides/pesticides also.