ANALYSIS OF THE EVOLUTION OF ANGIOTENSIN-II TYPE-1 RECEPTOR GENE IN MAMMALS (MOUSE, RAT, BOVINE AND HUMAN)

被引：99

作者：

YOSHIDA, H ^{[1
]}

KAKUCHI, J ^{[1
]}

GUO, DF ^{[1
]}

FURUTA, H ^{[1
]}

IWAI, N ^{[1
]}

VANDERMEERDEJONG, R ^{[1
]}

INAGAMI, T ^{[1
]}

ICHIKAWA, I ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90852-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleotide and amino acid sequences for mouse angiotensin II (AII) type 1A and 1B receptors were deduced from their complementary and genomic DNAs. Evolutionary analyses based on the nucleotide sequences of the coding region of AII type 1 receptor genes indicated that the duplication event of the type 1 gene occurred 24±2 million years ago before the divergence between the rat and mouse but after the divergence between rodents and the human/artiodactyls couple. This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene. © 1992.

引用

页码：1042 / 1049

页数：8

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