VASOPRESSIN DEFICIENCY ABOLISHES A SEXUALLY DIMORPHIC BEHAVIOR IN BRATTLEBORO RATS

被引：20

作者：

BROT, MD

BERNSTEIN, IL

DORSA, DM

机构：

[1] VET AFFAIRS MED CTR,GERIATR RES EDUC & CLIN CTR,1660 S COLUMBIAN WAY,SEATTLE,WA 98108

[2] UNIV WASHINGTON,DEPT PSYCHOL,SEATTLE,WA 98195

[3] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195

[4] UNIV WASHINGTON,DEPT PHARMACOL,SEATTLE,WA 98195

[5] UNIV WASHINGTON,DEPT PSYCHIAT & BEHAV SCI,SEATTLE,WA 98195

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 04期

关键词：

VASOPRESSIN; SEXUAL DIMORPHISM; TESTOSTERONE; BRATTLEBORO RATS; SEX DIFFERENCES; EXTINCTION; CONDITIONED TASTE AVERSION; DIABETES-INSIPIDUS;

D O I：

10.1016/0031-9384(92)90124-K

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The role of vasopressin (VP) in a sexually dimorphic behavior, the extinction of a conditioned taste aversion, was investigated in male and female rats of three different genotypes, This behavior was examined with a two bottle test in the wild-type Long-Evans (LE) rats, and then in partially VP deficient heterozygous (HET-BB) and completely VP deficient homozygous (HO-BB) Brattleboro rats. In Experiment 1. non-deprived male and female LE rats were given aversions to a sucrose solution by pairing it with a LiCl injection. The rate of extinction of the aversion upon reexposure to ad lib sucrose solution was examined and observed to be sexually dimorphic. Female LE rats extinguished at a significantly more rapid rate than males. Experiment 2 compared HET-BB and HO-BB male and female rats using the same paradigm. Neither of these VP-deficient groups showed sexual dimorphism of the extinction behavior. The data suggest that intact VP levels are necessary to observe the expression of this sexually dimorphic behavior.

引用

页码：839 / 843

页数：5

共 36 条

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