ENZYMES IN ORGANIC-SYNTHESIS .8. SYNTHESIS OF ENANTIOMERICALLY PURE PROSTAGLANDIN INTERMEDIATES BY ENZYMATIC TRANSESTERIFICATION OF (1S-STAR, 5R-STAR, 6R-STAR, 7R-STAR)-(+/-)-7-HYDROXY-6-HYDROXYMETHYL-2-OXABICYCLO[3.3.0]OCTAN-3-ONE

被引：0

作者：

WEIDNER, J ^{[1
]}

THEIL, F ^{[1
]}

KUNATH, A ^{[1
]}

SCHICK, H ^{[1
]}

机构：

[1] CENT INST ORGAN CHEM,RUDOWER CHAUSSEE 5,O-1199 BERLIN,GERMANY

来源：

LIEBIGS ANNALEN DER CHEMIE | 1991年 / 12期

关键词：

PROSTAGLANDIN INTERMEDIATES; ENZYMATIC TRANSFORMATIONS; LIPASES IN ORGANIC SOLVENTS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipase Amano PS is a suitable biocatalyst for the highly regioand enantioselective transesterification of the racemic prostaglandin building block (1S*,5R*,6R*,7R*)-(+/-)-7-hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one (rac-1) yielding (1S,5R,6R,7R)-(-)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo[3.3.0]octan-3-one (2) and the unreacted (1R,5S,6S,7S)-(+)-enantiomer ent-1.

引用

页码：1301 / 1303

页数：3