FREE-RADICALS AND MALARIA

被引：0

作者：

GOLENSER, J ^{[1
]}

MARVA, E ^{[1
]}

KAMIL, M ^{[1
]}

HEMPELMANN, E ^{[1
]}

COHEN, A ^{[1
]}

HAREL, R ^{[1
]}

CHEVION, M ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT CELLULAR BIOCHEM,IL-91010 JERUSALEM,ISRAEL

来源：

SOUTH AFRICAN JOURNAL OF SCIENCE | 1991年 / 87卷 / 11-12期

关键词：

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oxidative stress may affect the malaria parasite at each stage of its development. Ascorbic acid had a stage-dependent effect on the in vitro development of Plasmodium falciparum. Addition of ascorbic acid to the early stage (ring forms) increased hypoxanthine incorporation but prevented the development of trophozoites to mature forms of the plasmodium. We also used DNA degradation to monitor the levels of redox-active iron-containing structures that can catalyse or promote the production of free radicals. We found that DNA was degraded upon incubation with lysates of infected red blood cells. Ascorbic acid was found to enhance the efficiency of degradation whereas the chelating agent diethylnetriaminepentaacetic acid inhibited the effect.

引用

页码：584 / 587

页数：4

共 30 条

[1] THE CHEMISTRY OF FAVISM-INDUCING COMPOUNDS - THE PROPERTIES OF ISOURAMIL AND DIVICINE AND THEIR REACTION WITH GLUTATHIONE [J].

CHEVION, M ;

NAVOK, T ;

GLASER, G ;

MAGER, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 127 (02) :405-409

[2] SOME ROLES OF FREE-RADICALS IN MALARIA [J].

CLARK, IA ;

CHAUDHRI, G ;

COWDEN, WB .

FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (03) :315-321

[3]

CLARK IA, 1983, INFECT IMMUN, V39, P1

[4] ACTIVITY OF DIVICINE IN PLASMODIUM-VINCKEI-INFECTED MICE HAS IMPLICATIONS FOR TREATMENT OF FAVISM AND EPIDEMIOLOGY OF G-6-PD DEFICIENCY [J].

CLARK, IA ;

COWDEN, WB ;

HUNT, NH ;

MAXWELL, LE ;

MACKIE, EJ .

BRITISH JOURNAL OF HAEMATOLOGY, 1984, 57 (03) :479-487

[5] INJECTION OF FREE-RADICAL GENERATORS CAUSES PREMATURE ONSET OF TISSUE-DAMAGE IN MALARIA-INFECTED MICE [J].

CLARK, IA ;

MACKIE, EJ ;

COWDEN, WB .

JOURNAL OF PATHOLOGY, 1986, 148 (04) :301-305

[6]

ETKIN NL, 1975, ERYTHROCYTE STRUCTUR, P219

[7]

GOLENSER J, 1989, SEMIN HEMATOL, V26, P313

[8]

GOLENSER J, 1983, BLOOD, V61, P507

[9]

HEBBEL RP, 1989, SEMIN HEMATOL, V26, P136

[10] SECRETION OF A MALARIAL HISTIDINE RICH PROTEIN (PFHRP-II) FROM PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES [J].

HOWARD, RJ ;

UNI, S ;

AIKAWA, M ;

ALEY, SB ;

LEECH, JH ;

LEW, AM ;

WELLEMS, TE ;

RENER, J ;

TAYLOR, DW .

JOURNAL OF CELL BIOLOGY, 1986, 103 (04) :1269-1277

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