THE STRUCTURE OF ERYTHROMYCIN-A IN [H-2(6)]DMSO AND BUFFERED D2O - FULL ASSIGNMENTS OF THE H-1 AND C-13 NMR-SPECTRA

被引:16
作者
BARBER, J
GYI, JI
LIAN, L
MORRIS, GA
PYE, DA
SUTHERLAND, JK
机构
[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND
[2] UNIV LEICESTER,LEICESTER BIOL NMR CTR,LEICESTER LE1 9HN,ENGLAND
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1991年 / 10期
关键词
D O I
10.1039/p29910001489
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The H-1 and C-13 NMR spectra of erythromycin A in [H-2(6)]-DMSO and buffered D2O have been assigned using a range of one and two dimensional NMR techniques. Assignments have been made for both the major (keto) and minor forms of the drug, and the minor form has been shown to be the 12,9-cyclic hemiacetal.
引用
收藏
页码:1489 / 1494
页数:6
相关论文
共 19 条
[1]   ISOMERIZATION OF ERYTHROMYCIN-A IN DEUTERIUM-OXIDE AND [H-2(6)] DIMETHYL-SULFOXIDE SOLUTIONS - A H-1 AND C-13 NMR-STUDY [J].
BARBER, J ;
GYI, JI ;
MORRIS, GA ;
PYE, DA ;
SUTHERLAND, JK .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (15) :1040-1041
[2]   MLEV-17-BASED TWO-DIMENSIONAL HOMONUCLEAR MAGNETIZATION TRANSFER SPECTROSCOPY [J].
BAX, A ;
DAVIS, DG .
JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (02) :355-360
[3]   SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].
BAX, A ;
SUBRAMANIAN, S .
JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) :565-569
[4]   SECONDARY ISOTOPE MULTIPLET NMR-SPECTROSCOPY OF PARTIALLY LABELED ENTITIES - C-13 SIMPLE NMR OF CARBOHYDRATES [J].
CHRISTOFIDES, JC ;
DAVIES, DB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (15) :5099-5105
[5]   NMR STUDY OF SOME ERYTHROMYCIN AGLYCONES . A CONFORMATIONAL AND CONFIGURATIONAL ANALYSIS [J].
DEMARCO, PV .
JOURNAL OF ANTIBIOTICS, 1969, 22 (07) :327-&
[6]   CONFORMATIONAL FLEXIBILITY OF ERYTHRONOLIDE-B, 14-MEMBERED AGLYCON RING OF ERYTHROMYCINS [J].
EGAN, RS ;
MARTIN, JR ;
PERUN, TJ ;
MITSCHER, LA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (16) :4578-4583
[7]  
EGAN RS, 1973, TETRAHEDRON, P2525
[8]   AN ANALYSIS OF THE H-1 AND C-13 NMR-SPECTRA OF ERYTHROMYCIN-A USING TWO-DIMENSIONAL METHODS [J].
EVERETT, JR ;
TYLER, JW .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (12) :2599-2603
[9]   KETONE HEMIACETAL TAUTOMERISM IN ERYTHROMYCIN-A IN NONAQUEOUS SOLUTIONS - AN NMR SPECTROSCOPIC STUDY [J].
EVERETT, JR ;
HUNT, E ;
TYLER, JW .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1991, (10) :1481-1487
[10]   THE CONFORMATIONAL-ANALYSIS OF ERYTHROMYCIN-A [J].
EVERETT, JR ;
TYLER, JW .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1987, (11) :1659-1667