PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE ACTIVITY AND TRH AND CRF BIOSYNTHESIS - ROLE OF COPPER

被引：0

作者：

GIRAUD, P ^{[1
]}

MALTESE, JY ^{[1
]}

BOUDOURESQUE, F ^{[1
]}

SALERS, P ^{[1
]}

OUAFIK, L ^{[1
]}

RENARD, M ^{[1
]}

PELEN, F ^{[1
]}

OLIVER, C ^{[1
]}

机构：

[1] LAB LABCATAL,F-92541 MONTROUGE,FRANCE

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1992年 / 32卷

关键词：

TRACE ELEMENTS; COPPER; PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE; THYROTROPIN-RELEASING HORMONE; CORTICOTROPIN-RELEASING FACTOR;

D O I：

10.1007/BF02784614

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carboxy-terminal amidation of biologically active peptides, an important characteristic of more than half of these substances, occurs during the maturation process of peptide precursors. It is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme that is copper-dependent. We show here that alterations of copper stores in cultured cells from different origins (pancreas and hypothalamus) affect the immunoreactivity of thyrotropin-releasing hormone (TRH) and corticotropin-releasing factor (CRF) (two alpha-amidated peptides). This suggests that copper can affect neuropeptide biosynthesis and may play a role in the endocrine or central nervous system function.

引用

页码：293 / 301

页数：9

共 26 条

[11] ALPHA-AMIDATION OF GASTRIN IS IMPAIRED BY DIETHYLDITHIOCARBAMATE
HILSTED, L
[J]. REGULATORY PEPTIDES, 1990, 29 (2-3) : 179 - 187
[12] THYROTROPIN-RELEASING-HORMONE (TRH) - DISTRIBUTION IN HYPOTHALAMIC AND EXTRAHYPOTHALAMIC BRAIN-TISSUES OF MAMMALIAN AND SUBMAMMALIAN CHORDATES
JACKSON, IMD
REICHLIN, S
[J]. ENDOCRINOLOGY, 1974, 95 (03) : 854 - 862
[13] THYROTROPIN-RELEASING FACTOR - DISTRIBUTION IN NEURAL AND GASTROINTESTINAL TISSUES
LEPPALUOTO, J
KOIVUSALO, F
KRAAMA, R
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1978, 104 (02): : 175 - 179
[14] LOH YP, 1984, ANN REV NEUROSCI, V7, P180
[15] HORMONAL, DRUG, AND DIETARY FACTORS AFFECTING PEPTIDYL GLYCINE ALPHA-AMIDATING MONOOXYGENASE ACTIVITY IN VARIOUS TISSUES OF THE ADULT MALE-RAT
MAINS, RE
MYERS, AC
EIPPER, BA
[J]. ENDOCRINOLOGY, 1985, 116 (06) : 2505 - 2515
[16] MAINS RE, 1986, BIOL CHEM, V261, P938
[17] CARBOXY TERMINUS OF VASOPRESSIN REQUIRED FOR ACTIVITY BUT NOT BINDING
MANNING, M
OLMA, A
KLIS, W
KOLODZIEJCZYK, A
NAWROCKA, E
MISICKA, A
SETO, J
SAWYER, WH
[J]. NATURE, 1984, 308 (5960) : 652 - 653
[18] MARCHAND JE, 1990, J BIOL CHEM, V265, P264
[19] HIGH-CONCENTRATION OF THYROTROPIN-RELEASING-HORMONE IN PANCREATIC-ISLETS
MARTINO, E
LERNMARK, A
SEO, H
STEINER, DF
REFETOFF, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (09) : 4265 - 4267
[20] EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON THE ENDOCRINE PANCREAS
MORLEY, JE
LEVIN, SR
PEHLEVANIAN, M
ADACHI, R
PEKARY, AE
HERSHMAN, JM
[J]. ENDOCRINOLOGY, 1979, 104 (01) : 137 - 139

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