PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE ACTIVITY AND TRH AND CRF BIOSYNTHESIS - ROLE OF COPPER

被引：0

作者：

GIRAUD, P ^{[1
]}

MALTESE, JY ^{[1
]}

BOUDOURESQUE, F ^{[1
]}

SALERS, P ^{[1
]}

OUAFIK, L ^{[1
]}

RENARD, M ^{[1
]}

PELEN, F ^{[1
]}

OLIVER, C ^{[1
]}

机构：

[1] LAB LABCATAL,F-92541 MONTROUGE,FRANCE

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1992年 / 32卷

关键词：

TRACE ELEMENTS; COPPER; PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE; THYROTROPIN-RELEASING HORMONE; CORTICOTROPIN-RELEASING FACTOR;

D O I：

10.1007/BF02784614

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carboxy-terminal amidation of biologically active peptides, an important characteristic of more than half of these substances, occurs during the maturation process of peptide precursors. It is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme that is copper-dependent. We show here that alterations of copper stores in cultured cells from different origins (pancreas and hypothalamus) affect the immunoreactivity of thyrotropin-releasing hormone (TRH) and corticotropin-releasing factor (CRF) (two alpha-amidated peptides). This suggests that copper can affect neuropeptide biosynthesis and may play a role in the endocrine or central nervous system function.

引用

页码：293 / 301

页数：9

共 26 条

[1] EXTRACELLULAR CALCIUM IS REQUIRED FOR COPPER-AMPLIFIED PROSTAGLANDIN-E2 STIMULATION OF THE RELEASE OF GONADOTROPIN-RELEASING-HORMONE FROM MEDIAN-EMINENCE EXPLANTS
BARNEA, A
CHO, G
COLOMBANIVIDAL, M
[J]. ENDOCRINOLOGY, 1986, 119 (03) : 1262 - 1267
[2] EVIDENCE THAT COPPER AMINO-ACID COMPLEXES ARE POTENT STIMULATORS OF THE RELEASE OF LUTEINIZING-HORMONE-RELEASING HORMONE FROM ISOLATED HYPOTHALAMIC GRANULES
BARNEA, A
CHO, G
[J]. ENDOCRINOLOGY, 1984, 115 (03) : 936 - 943
[3] MECHANISM OF C-TERMINAL AMIDE FORMATION BY PITUITARY ENZYMES
BRADBURY, AF
FINNIE, MDA
SMYTH, DG
[J]. NATURE, 1982, 298 (5875) : 686 - 688
[4] BUGNON C, 1982, CR ACAD SCI III-VIE, V294, P279
[5] REGULATION OF TRH RELEASE BY THE CULTURED NEONATE RAT PANCREAS
DUTOUR, A
GIRAUD, P
MALTESE, JY
BECQUET, D
PESCE, G
SALERS, P
OUAFIK, L
RENARD, M
OLIVER, C
[J]. PEPTIDES, 1990, 11 (06) : 1081 - 1085
[6] ONTOGENY OF TRH MESSENGER-RNA IN THE RAT PANCREAS
DUTOUR, A
GIRAUD, P
KOWALSKI, C
OUAFIK, LH
SALERS, P
STRBAK, V
OLIVER, C
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (01) : 354 - 360
[7] IDENTIFICATION IN PITUITARY TISSUE OF A PEPTIDE ALPHA-AMIDATION ACTIVITY THAT ACTS ON GLYCINE-EXTENDED PEPTIDES AND REQUIRES MOLECULAR-OXYGEN, COPPER, AND ASCORBIC-ACID
EIPPER, BA
MAINS, RE
GLEMBOTSKI, CC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16): : 5144 - 5148
[8] ISOLATION AND CHARACTERIZATION OF A VARIANT FORM OF VASOACTIVE INTESTINAL POLYPEPTIDE
GAFVELIN, G
ANDERSSON, M
DIMALINE, R
JORNVALL, H
MUTT, V
[J]. PEPTIDES, 1988, 9 (03) : 469 - 474
[9] THE CORTICOTROPIN-RELEASING FACTOR RELEASE IN RAT HYPOPHYSEAL PORTAL BLOOD IS MEDIATED BY BRAIN CATECHOLAMINES
GUILLAUME, V
CONTEDEVOLX, B
SZAFARCZYK, A
MALAVAL, F
PARESHERBUTE, N
GRINO, M
ALONSO, G
ASSENMACHER, I
OLIVER, C
[J]. NEUROENDOCRINOLOGY, 1987, 46 (02) : 143 - 146
[10] METHOD FOR LARGE-SCALE ISOLATION OF PANCREATIC-ISLETS BY TISSUE-CULTURE OF FETAL RAT PANCREAS
HELLERSTROM, C
LEWIS, NJ
BORG, H
JOHNSON, R
FREINKEL, N
[J]. DIABETES, 1979, 28 (08) : 769 - 776

← 1 2 3 →