alpha-GLUCOSIDASE AND alpha -AMYLASE INHIBITORY ACTIVITIES OF RAPHANUS SATIVUS LINN

被引：2

作者：

Vadivelan, Ramachandran ^{[1
]}

Dhanabal, Sanagai Palaniswami ^{[2
]}

Wadhawani, Ashish ^{[3
]}

Elango, Kannan ^{[1
]}

机构：

[1] JSS Coll Pharm, Dept Pharmacol, Campus JSS Univ, Nilgiris 643001, Karnataka, India

[2] JSS Coll Pharm, Dept Phytopharm & Phytomed, Nilgiris 643001, Karnataka, India

[3] JSS Coll Pharm, Dept Biotechnol, Nilgiris 643001, Karnataka, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 09期

关键词：

Raphanus sativus; alpha-Glucosidase/alpha -amylase inhibitor; Diabetes; Nilgiris;

D O I：

10.13040/IJPSR.0975-8232.3(9).3186-88

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study is to evaluate the invitro antidiabetic activity of Raphanus sativus ethanolic extract and fractions by alpha-glucosidase and alpha -amylase inhibitory activity. Raphanus sativus ethanolic extract and fractions showed dose dependent inhibition of alpha- glucosidase and alpha -amylase enzyme and exhibited lower inhibitory activity than acarbose. The study revealed the antidiabetic potential and could be helpful to develop medicinal preparations and nutraceuticals and function foods for diabetes.

引用

页码：3186 / 3188

页数：3

共 50 条

[21] PHYTOCHEMICAL ANALYSIS OF ELATERIOSPERMUM TAPOS AND ITS INHIBITORY EFFECTS ON ALPHA-AMYLASE, ALPHA-GLUCOSIDASE AND PANCREATIC LIPASE
Nor-Liyana, J.
Siroshini, K. T.
Nurul-Syahirah, M. B.
Chang, W. L.
Nurul-Husna, S.
Daryl, J. A.
Khairul-Kamilah, A. K.
Hasnah, B.
JOURNAL OF TROPICAL FOREST SCIENCE, 2019, 31 (02) : 240 - 248
[22] Inhibitory effects of five medicinal plants on rat alpha-glucosidase: Comparison with their effects on yeast alpha-glucosidase
Shai, L. J.
Magano, S. R.
Lebelo, S. L.
Mogale, A. M.
JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, 5 (13): : 2863 - 2867
[23] Alpha-glucosidase Inhibitory Activity of Mormodica charantia
Obih, Patience Ogechi
Nguyen, Anthony
Obih, John-Clifford Agbasi
FASEB JOURNAL, 2016, 30
[24] In vitro antioxidant activities of African birch (Anogeissus leiocarpus) leaf and its effect on the alpha-amylase and alpha-glucosidase inhibitory properties of acarbose
Adefegha, Stephen A.
Oboh, Ganiyu
Omojokun, Olasunkanmi S.
Jimoh, Tajudeen O.
Oyeleye, Sunday I.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES, 2016, 11 (03): : 236 - 242
[25] EFFECT OF ALPHA-GLUCOSIDASE INHIBITOR ON HUMAN PANCREATIC AND SALIVARY ALPHA-AMYLASE
SUEHIRO, I
OTSUKI, M
YAMASAKI, T
OHKI, A
SAKAMOTO, C
YUU, H
MAEDA, M
BABA, S
CLINICA CHIMICA ACTA, 1981, 117 (02) : 145 - 152
[26] In vitro and in vivo studies on the alpha-glucosidase inhibitory effects of the leaf extract of Carica papaya Linn
Abubakar M.
Onyike E.
Ibrahim M.A.
Comparative Clinical Pathology, 2019, 28 (4) : 1061 - 1067
[27] INFLUENCE OF ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITORS ON ORAL STARCH METABOLISM
MORMANN, JE
MUHLEMANN, HR
LEBENSMITTEL-WISSENSCHAFT & TECHNOLOGIE, 1981, 14 (03): : 166 - 169
[28] Inhibition of alpha-amylase and alpha-glucosidase by Acanthus montanus Leaf Extracts
Ogundajo, Akintayo L.
Kazeem, Mutiu I.
Owoyele, Olamidisun A.
Ogunmoye, Abdul Razak O.
Ogunwande, Isiaka A.
BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2016, 9 (02):
[29] ALPHA-AMYLASE, LIMIT DEXTRINASE, AND ALPHA-GLUCOSIDASE ENZYMES IN BARLEY AND MALT
MACGREGOR, AW
CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, 1987, 5 (02): : 117 - 128
[30] THERMOSTABLE EXTRACELLULAR ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE OF LIPOMYCES-STARKEYI
KELLY, CT
MORIARTY, ME
FOGARTY, WM
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1985, 22 (05) : 352 - 358

← 1 2 3 4 5 →