PATTERNS OF DONOR-TYPE MICROCHIMERISM AFTER HEART-TRANSPLANTATION

被引：129
作者：
SCHLITT, HJ [1 ]
HUNDRIESER, J [1 ]
HISANAGA, M [1 ]
UTHOFF, K [1 ]
KARCK, M [1 ]
WAHLERS, T [1 ]
WONIGEIT, K [1 ]
PICHLMAYR, R [1 ]
机构：
[1] HANNOVER MED SCH,THORAX HERZ & GEFASSCHIRURG KLIN,D-30623 HANNOVER,GERMANY
来源：
LANCET | 1994年 / 343卷 / 8911期
关键词：
D O I：
10.1016/S0140-6736(94)92584-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Allogeneic microchimerism of donor-type has been demonstrated in stable patients in the long-term after organ transplantation. We have analysed microchimerism in shin and blood of 47 heart-transplanted patients after transplantation with polymerase-chain-reaction amplification specific for donor HLA-DRB1. Microchimerism was detectable in 50% of the patients in the first 6 months, in 100% between 6 months and 2 years, and in 58% in the third postoperative year or later. The state of chimerism was not related to acute or chronic rejections. Patterns of microchimerism after heart transplantation may be dynamic, but any association with clinical and immunological variables remains to be elucidated.
引用
收藏
页码：1469 / 1471
页数：3
相关论文
共 10 条
  • [1] RAPID HLA-DRB1 GENOTYPING BY NESTED PCR-AMPLIFICATION
    BEIN, G
    GLASER, R
    KIRCHNER, H
    [J]. TISSUE ANTIGENS, 1992, 39 (02): : 68 - 73
  • [2] EVIDENCE OF A NATURAL-KILLER (NK) CELL REPERTOIRE FOR (ALLO) ANTIGEN RECOGNITION - DEFINITION OF 5 DISTINCT NK-DETERMINED ALLOSPECIFICITIES IN HUMANS
    CICCONE, E
    PENDE, D
    VIALE, O
    DIDONATO, C
    TRIPODI, G
    ORENGO, AM
    GUARDIOLA, J
    MORETTA, A
    MORETTA, L
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) : 709 - 718
  • [3] DEMETRIS AJ, 1993, TRANSPL P, V25, P3337
  • [4] THE ROLE OF GRAFT-DERIVED DENDRITIC LEUKOCYTES IN THE REJECTION OF VASCULARIZED ORGAN ALLOGRAFTS - RECENT FINDINGS ON THE MIGRATION AND FUNCTION OF DENDRITIC LEUKOCYTES AFTER TRANSPLANTATION
    LARSEN, CP
    AUSTYN, JM
    MORRIS, PJ
    [J]. ANNALS OF SURGERY, 1990, 212 (03) : 308 - 317
  • [5] QIAN S, IN PRESS HEPATOLOGY
  • [6] DONOR-TYPE MICROCHIMERISM ASSOCIATED WITH GRAFT-REJECTION 8 YEARS AFTER LIVER-TRANSPLANTATION
    SCHLITT, HJ
    HUNDRIESER, J
    RINGE, B
    PICHLMAYR, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (09) : 646 - 647
  • [7] PASSENGER LYMPHOCYTES IN HUMAN LIVER ALLOGRAFTS AND THEIR POTENTIAL ROLE AFTER TRANSPLANTATION
    SCHLITT, HJ
    RADDATZ, G
    STEINHOFF, G
    WONIGEIT, K
    PICHLMAYR, R
    [J]. TRANSPLANTATION, 1993, 56 (04) : 951 - 955
  • [8] SCHLITT HJ, 1992, TRANSPLANTATION, V56, P1001
  • [9] CHIMERISM AND DONOR-SPECIFIC NONREACTIVITY 27 TO 29 YEARS AFTER KIDNEY ALLOTRANSPLANTATION
    STARZL, TE
    DEMETRIS, AJ
    TRUCCO, M
    ZEEVI, A
    RAMOS, H
    TERASAKI, P
    RUDERT, WA
    KOCOVA, M
    RICORDI, C
    ILDSTAD, S
    MURASE, N
    [J]. TRANSPLANTATION, 1993, 55 (06) : 1272 - 1277
  • [10] SYSTEMIC CHIMERISM IN HUMAN FEMALE RECIPIENTS OF MALE LIVERS
    STARZL, TE
    DEMETRIS, AJ
    TRUCCO, M
    RAMOS, H
    ZEEVI, A
    RUDERT, WA
    KOCOVA, M
    RICORDI, C
    ILDSTAD, S
    MURASE, N
    [J]. LANCET, 1992, 340 (8824) : 876 - 877
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