Oncolytic viral therapy for pancreatic cancer: current research and future directions

被引：16

作者：

Ady, Justin W. ^{[1
]}

Heffner, Jacqueline ^{[1
]}

Klein, Elizabeth ^{[1
]}

Fong, Yuman ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA

来源：

ONCOLYTIC VIROTHERAPY | 2014年 / 3卷

关键词：

pancreatic cancer; oncolytic virus; review;

D O I：

10.2147/OV.S53858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of targeted agents and chemotherapies for pancreatic cancer has only modestly affected clinical outcome and not changed 5-year survival. Fortunately the genetic and molecular mechanisms underlying pancreatic cancer are being rapidly uncovered and are providing opportunities for novel targeted therapies. Oncolytic viral therapy is one of the most promising targeted agents for pancreatic cancer. This review will look at the current state of the development of these self-replicating nanoparticles in the treatment of pancreatic cancer.

引用

页码：35 / 46

页数：12

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