BRUTON TYROSINE KINASE IS TYROSINE-PHOSPHORYLATED AND ACTIVATED IN PRE-B LYMPHOCYTES AND RECEPTOR-LIGATED B-CELLS

被引：184

作者：

AOKI, Y

ISSELBACHER, KJ

PILLAI, S

机构：

[1] MASSACHUSETTS GEN HOSP,CTR CANC,BOSTON,MA 02129

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02129

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 22期

关键词：

X CHROMOSOME LINKED AGAMMAGLOBULINEMIA; PRE-ANTIGEN RECEPTOR; B-CELL SIGNALING;

D O I：

10.1073/pnas.91.22.10606

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene encoding Bruton tyrosine kinase (Btk) is known to be mutated in human X chromosome-linked agammaglobulinemia and in the Xid mouse. This kinase was examined in B lymphocytes before and after antigen receptor ligation and also in pre-B cells. Btk was found to be catalytically activated and tyrosine phosphorylated in response to anti-IgM stimulation in B cells. This kinase is also constitutively phosphorylated on tyrosine residues in pre-B cells. These findings point to a functional role for Btk in pre-antigen and antigen receptor signaling during B-cell development and provide a biochemical explanation for the X-linked genetic syndromes already linked to this kinase.

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页码：10606 / 10609

页数：4

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