MURINE IGG SUBCLASS ANTIBODIES TO ANTIGENS INCORPORATED IN LIPOSOMES CONTAINING LIPID-A

被引：16

作者：

GLENN, GM

RAO, M

RICHARDS, RL

MATYAS, GR

ALVING, CR

机构：

[1] Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington

来源：

IMMUNOLOGY LETTERS | 1995年 / 47卷 / 1-2期

关键词：

IGG SUBCLASS RESPONSE; LIPID A; SPF66; CHOLERA TOXIN; BALB/C MOUSE;

D O I：

10.1016/0165-2478(95)00069-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IgG subclass responses to antigens incorporated in liposomes containing lipid A were investigated using a synthetic malarial antigen (SPf66) and cholera toxin (CT). The antigen-specific IgG subclass response was determined in BALB/c mice immunized with either: (a) SPf66 encapsulated in liposomes containing lipid A, (b) CVT bound to the surface of liposomes containing lipid A, or (c) both encapsulated SPf65 and surface-bound CT in the same liposomes. In each case the antibodies to SPf66, CT and lipid A demonstrated an IgG2a predominance. Liposomes containing lipid A not only increased the magnitude of the antibody response to liposomal antigens but elicited predominantly IgG2a subclass antibodies as well.

引用

页码：73 / 78

页数：6

共 17 条

[1] AN ADJUVANT FORMULATION THAT SELECTIVELY ELICITS THE FORMATION OF ANTIBODIES OF PROTECTIVE ISOTYPES AND OF CELL-MEDIATED-IMMUNITY [J].