EFFECT OF LOW PROTEIN-DIET ON MANGANESE NEUROTOXICITY .3. BRAIN NEUROTRANSMITTER LEVELS

被引：0
|
作者：
ALI, MM
MURTHY, RC
MANDAL, SK
CHANDRA, SV
机构：
[1] IND TOXICOL RES CTR, MET TOXIC, POB 80, LUCKNOW 226001, UTTAR PRADESH, INDIA
[2] CENT DRUG RES INST, DIV BIOMETRY & STAT, LUCKNOW 226001, UTTAR PRADESH, INDIA
来源：
NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY | 1985年 / 7卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The effect of concurrent low protein (10% casein) diet and manganese (Mn) exposure (3 mg/ml drinking water) on brain levels of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT) were investigated in Fo-growing (90 days exposure), Fo-diet rehabilitated (low .fwdarw. normal protein diet-28 days) and FI-weaned rats. Mn exposure in either diet group resulted in a significant increase in the DA and NE levels but a decrease in the 5-HT level. These effects were more pronounced in the rats fed the low protein diet, especially in the F1-offsprings. Diet rehabilitation reduced the effects of Mn exposure.
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页码：427 / 431
页数：5
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