PERSISTENCE OF LONG-LASTING SEROTONIN DEPLETION BY P-CHLOROAMPHETAMINE IN RAT-BRAIN AFTER 6-HYDROXYDOPAMINE LESIONING OF DOPAMINE NEURONS

被引：6

作者：

PERRY, KW

KOSTRZEWA, RM

FULLER, RW

机构：

[1] ELI LILLY & CO,LILLY RES LABS,INDIANAPOLIS,IN 46185

[2] E TENNESSEE STATE UNIV,SCH MED,JOHNSON CITY,TN 37614

来源：

BIOCHEMICAL PHARMACOLOGY | 1995年 / 50卷 / 08期

关键词：

P-CHLOROAMPHETAMINE; SEROTONIN; DOPAMINE; 6-HYDROXYDOPAMINE; STRIATUM; HIPPOCAMPUS;

D O I：

10.1016/0006-2952(95)00248-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In rats that had been treated neonatally with 6-hydroxydopamine (6OHDA) to deplete striatal dopamine more than 95%, a single injection of p-chloroamphetamine (pCA) (5 or 10 mg/kg, i.p.) resulted in depletion of striatal and hippocampal serotonin at 1 week to a similar extent as in control rats. These findings suggest that striatal dopamine is not essential to the long-lasting depletion of brain serotonin by pCA in rats.

引用

页码：1305 / 1307

页数：3

共 17 条

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