CHARACTERISTICS OF THE T-CELL-MEDIATED IMMUNE-RESPONSE TO MAEDI-VISNA VIRUS

被引：18

作者：

REYBURN, HT ^{[1
]}

ROY, DJ ^{[1
]}

BLACKLAWS, BA ^{[1
]}

SARGAN, DR ^{[1
]}

WATT, NJ ^{[1
]}

MCCONNELL, I ^{[1
]}

机构：

[1] UNIV EDINBURGH, DEPT VET PATHOL, EDINBURGH EH9 1QH, MIDLOTHIAN, SCOTLAND

来源：

VIROLOGY | 1992年 / 191卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0042-6822(92)90282-T

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. The responding T cell population in this assay was mainly of the CD4+ phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system. © 1992.

引用

页码：1009 / 1012

页数：4

共 24 条

[1] SEPARATION OF WHITE BLOOD CELLS [J].

BOYUM, A .

NATURE, 1964, 204 (496) :793-&

[2] THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO [J].

COBBOLD, SP ;

JAYASURIYA, A ;

NASH, A ;

PROSPERO, TD ;

WALDMANN, H .

NATURE, 1984, 312 (5994) :548-551

[3] TROPISM OF SHEEP LENTIVIRUSES FOR MONOCYTES - SUSCEPTIBILITY TO INFECTION AND VIRUS GENE-EXPRESSION INCREASE DURING MATURATION OF MONOCYTES TO MACROPHAGES [J].

GENDELMAN, HE ;

NARAYAN, O ;

KENNEDYSTOSKOPF, S ;

KENNEDY, PGE ;

GHOTBI, Z ;

CLEMENTS, JE ;

STANLEY, J ;

PEZESHKPOUR, G .

JOURNAL OF VIROLOGY, 1986, 58 (01) :67-74

[4] THE INS AND OUTS OF ANTIGEN PROCESSING AND PRESENTATION [J].

GERMAIN, RN .

NATURE, 1986, 322 (6081) :687-689

[5] SEQUENCE HOMOLOGY AND MORPHOLOGIC SIMILARITY OF HTLV-III AND VISNA VIRUS, A PATHOGENIC LENTI-VIRUS [J].

GONDA, MA ;

WONGSTAAL, F ;

GALLO, RC ;

CLEMENTS, JE ;

NARAYAN, O ;

GILDEN, RV .

SCIENCE, 1985, 227 (4683) :173-177

[6] EARLY IMMUNE-RESPONSES IN VISNA, A SLOW VIRAL DISEASE OF SHEEP [J].

GRIFFIN, DE ;

NARAYAN, O ;

ADAMS, RJ .

JOURNAL OF INFECTIOUS DISEASES, 1978, 138 (03) :340-350

[7] PROTECTIVE CELLULAR RETROVIRAL IMMUNITY REQUIRES BOTH CD4+ AND CD8+ IMMUNE T-CELLS [J].

HOM, RC ;

FINBERG, RW ;

MULLANEY, S ;

RUPRECHT, RM .

JOURNAL OF VIROLOGY, 1991, 65 (01) :220-224

[8]

LAIRMORE MD, 1988, AM J PATHOL, V130, P80

[9] REPLICATION AND CYTOPATHIC EFFECTS OF OVINE LENTIVIRUS STRAINS IN ALVEOLAR MACROPHAGES CORRELATE WITH INVIVO PATHOGENICITY [J].

LAIRMORE, MD ;

AKITA, GY ;

RUSSELL, HI ;

DEMARTINI, JC .

JOURNAL OF VIROLOGY, 1987, 61 (12) :4038-4042

[10]

LARSEN HJ, 1982, AM J VET RES, V43, P384

← 1 2 3 →