STEREOSPECIFIC SYNTHESIS OF (+)-MURICATACIN - A BIOLOGICALLY-ACTIVE ACETOGENIN DERIVATIVE

被引：70

作者：

FIGADERE, B

HARMANGE, JC

LAURENS, A

CAVE, A

机构：

[1] Laboratoire de Pharmacognosie, associé au C.N.R.S. Faculté de Pharmacie

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 51期

关键词：

ACETOGENINS; MURICATACIN; SYNTHESIS; BIOASSAYS; ANNONA MURICATA;

D O I：

10.1016/0040-4039(91)80528-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-muricatacin and analogs have been synthesized without ambiguity about the absolute configuration at the C-4 and C-5 centres. The observed [alpha]D are reported as well as the results obtained for the cytotoxicity assay with KB and VERO cell lines.

引用

页码：7539 / 7542

页数：4

共 9 条

[1] CAHIEZ G, COMMUNICATION
[2] COROSSOLONE AND COROSSOLINE, 2 NEW CYTOTOXIC MONOTETRAHYDROFURAN GAMMA-LACTONES
CORTES, D
MYINT, SH
LAURENS, A
HOCQUEMILLER, R
LEBOEUF, M
CAVE, A
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1991, 69 (01) : 8 - 11
[3] DANA G, 1967, B SOC CHIM FR, P3308
[4] LALANDE J, 1987, B SOC CHIM FR, P116
[5] MYINT SH, 1990, HETEROCYCLES, V31, P861
[6] MYINT SH, 1991, PHYTOCHEMISTRY, V30, P3335, DOI 10.1016/0031-9422(91)83204-X
[7] MURICATACIN - A SIMPLE BIOLOGICALLY-ACTIVE ACETOGENIN DERIVATIVE FROM THE SEEDS OF ANNONA-MURICATA (ANNONACEAE)
RIESER, MJ
KOZLOWSKI, JF
WOOD, KV
MCLAUGHLIN, JL
[J]. TETRAHEDRON LETTERS, 1991, 32 (09) : 1137 - 1140
[8] ANNONACEOUS ACETOGENINS - A REVIEW
RUPPRECHT, JK
HUI, YH
MCLAUGHLIN, JL
[J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (02): : 237 - 278
[9] SCHOLTZ G, 1991, TETRAHEDRON LETT, V40, P5535

← 1 →